# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3425226 | Binding | Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells by gamma counting analysis | Homo sapiens | 6 | ALA3421530 | cell-based format | Scientific Literature | |
2. | ALA3425227 | Binding | Displacement of [125I]-NDP-alpha-MSH from human MC3 receptor expressed in HEK293 cells at 10 uM by gamma counting analysis | Homo sapiens | 6 | ALA3421530 | cell-based format | Scientific Literature | |
3. | ALA3425228 | Functional | Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation by luminescence counter | Homo sapiens | 6 | ALA3421530 | cell-based format | Scientific Literature | |
4. | ALA3425229 | Functional | Activity at human MC3 receptor expressed in HEK293 cells assessed as cAMP accumulation at 10 uM by luminescence counter relative to MT-II | Homo sapiens | 6 | ALA3421530 | cell-based format | Scientific Literature | |
5. | ALA3602967 | Binding | Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells after 40 mins by luminescence counting | Homo sapiens | 32 | ALA3600284 | cell-based format | Scientific Literature | |
6. | ALA3602968 | Binding | Displacement of [125I]-[Nle4,D-Phe7]-alpha-MSH from human MC3 receptor expressed in HEK293 cells at 10 uM after 40 mins by luminescence counting relative to control | Homo sapiens | 32 | ALA3600284 | cell-based format | Scientific Literature | |
7. | ALA3602975 | Functional | Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP by luminescence counting | Homo sapiens | 32 | ALA3600284 | cell-based format | Scientific Literature | |
8. | ALA3602976 | Functional | Agonist activity at human MC3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation using [3H]-cAMP at 10 uM by luminescence counting relative to MT-II | Homo sapiens | 32 | ALA3600284 | cell-based format | Scientific Literature | |
9. | ALA3603188 | Functional | Antagonist activity at human MC3 receptor expressed in HEK293 cells assessed as inhibition of MT-II-induced intracellular cAMP accumulation using [3H]-cAMP by luminescence counting | Homo sapiens | 4 | ALA3600284 | cell-based format | Scientific Literature | |
10. | ALA3755536 | Binding | Displacement of 125I-labeled [Nle4,DPhe7]-alpha-MSH from human melanocortin 3 receptor expressed in HEK293 cells incubated for 40 mins by gamma counting analysis | Homo sapiens | 5 | ALA3751760 | cell-based format | Scientific Literature | |
11. | ALA3755540 | Functional | Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation incubated for 3 mins in presence of IBMX | Homo sapiens | 4 | ALA3751760 | cell-based format | Scientific Literature | |
12. | ALA3755545 | Functional | Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP accumulation incubated for 3 mins relative to MT-2 | Homo sapiens | 3 | ALA3751760 | cell-based format | Scientific Literature | |
13. | ALA3755733 | Functional | Agonist activity at human melanocortin 3 receptor expressed in HEK293 cells assessed as intracellular cAMP accumulation at 10 uM incubated for 3 mins in presence of IBMX | Homo sapiens | 1 | ALA3751760 | cell-based format | Scientific Literature | |
14. | ALA691188 | Functional | In vitro agonist potency was evaluated in HEK293 cells transfected with human melanocortin receptor (hMC3R) | 25 | ALA1136147 | cell-based format | Scientific Literature | ||
15. | ALA708675 | Functional | Evaluated for Functional Activity at MC3R as % of cAMP accumulation at 10 uM relative to alpha-MSH | 1 | ALA1135618 | assay format | Scientific Literature | ||
16. | ALA708676 | Functional | Maximum percentage of cAMP accumulation at 10 uM relative to alpha-MSH at MC3R | 6 | ALA1135618 | assay format | Scientific Literature | ||
17. | ALA708677 | Functional | Evaluated for Functional Activity at MC3R as effective concentration at 50% maximum CMP accumulation | 2 | ALA1135618 | assay format | Scientific Literature | ||
18. | ALA708678 | Functional | Functional activity as concentration at 50% maximum cAMP accumulation in human melanocortin 1 (MC3R) receptor | 1 | ALA1135618 | assay format | Scientific Literature | ||
19. | ALA716349 | Binding | Percent activation of human melanocortin receptor Melanocortin 3 receptor was determined at 10 uM | 3 | ALA1145056 | single protein format | Scientific Literature | ||
20. | ALA716350 | Functional | Antagonist activity against human Melanocortin 3 receptor at 10 uM | Homo sapiens | 13 | ALA1144940 | assay format | Scientific Literature |