| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3783608 | B | Inhibition of MTH1 in human U2OS cells assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate at higher concentration after 1 hr by PPiLight assay | Homo sapiens | 2 | ALA3779767 | cell-based format | Scientific Literature | |
| 2. | ALA3783609 | B | Inhibition of MTH1 in human U2OS cell lysates assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate at 1 pM to 10 uM after 1 hr by PPiLight assay | Homo sapiens | 4 | ALA3779767 | cell-based format | Scientific Literature | |
| 3. | ALA3783612 | B | Binding affinity to recombinant MTH1 (unknown origin) by isothermal titration calorimetry | Homo sapiens | 1 | ALA3779767 | single protein format | Scientific Literature | |
| 4. | ALA3782136 | B | Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assay | Homo sapiens | 19 | ALA3779767 | single protein format | Scientific Literature | |
| 5. | ALA3782137 | B | Inhibition of recombinant human MTH1 assessed as hydrolysis of dGTP to dGMP and pyrophosphate after 15 mins by malachite green-based microplate reader analysis | Homo sapiens | 2 | ALA3779767 | single protein format | Scientific Literature | |
| 6. | ALA3782418 | B | Inhibition of MTH1 in human U2OS cells assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate at 1 pM to 10 uM after 1 hr by PPiLight assay | Homo sapiens | 2 | ALA3779767 | cell-based format | Scientific Literature | |
| 7. | ALA3782419 | B | Inhibition of MTH1 in human U2OS cells assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate after 1 hr by PPiLight assay | Homo sapiens | 1 | ALA3779767 | cell-based format | Scientific Literature | |
| 8. | ALA3796259 | B | Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate | Homo sapiens | 5 | ALA3792285 | single protein format | Scientific Literature | |
| 9. | ALA3796329 | B | Inhibition of recombinant human MTH1 expressed in Escherichia coli BL21 DE3 cells preincubated for 15 mins followed by 8-oxo-dGTP substrate addition measured after 15 mins by luminescence based assay | Homo sapiens | 2 | ALA3792285 | cell-based format | Scientific Literature | |
| 10. | ALA3877225 | B | Inhibition of human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) in presence of dGTP and inorganic pyrophosphatase incubated for 15 mins with shaking by malachite green assay | Homo sapiens | 2 | ALA3875233 | assay format | Scientific Literature | |
| 11. | ALA3877226 | B | Inhibition of DsRed-fused MTH1 (unknown origin) expressed in HEK293T cells using 8-oxo-dGTP as substrate | Homo sapiens | 2 | ALA3875233 | cell-based format | Scientific Literature | |
| 12. | ALA3877227 | B | Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate preincubated with protein followed by substrate addition measured over 15 mins by luminescence-based assay | Homo sapiens | 1 | ALA3875233 | assay format | Scientific Literature | |
| 13. | ALA3877228 | B | Inhibition of His-tagged human MTH1 expressed in Escherichia coli BL21 (DE3) using 2-OH-dATP as substrate preincubated with protein followed by substrate addition measured over 15 mins by luminescence-based assay | Homo sapiens | 1 | ALA3875233 | assay format | Scientific Literature | |
| 14. | ALA4008385 | B | Inhibition of recombinant human MTH1 using dGTP as substrate after 1 hr by malachite green reagent based assay | Homo sapiens | 1 | ALA4007403 | single protein format | Scientific Literature | |
| 15. | ALA4020046 | B | Inhibition of human recombinant His-tagged MTH1 expressed in Escherichia coli BL21 at 125 uM using dGTP as substrate after 1 hr by malachite green reagent-based assay relative to control | Homo sapiens | 5 | ALA4017528 | assay format | Scientific Literature | |
| 16. | ALA4020047 | B | Inhibition of human recombinant His-tagged MTH1 expressed in Escherichia coli BL21 using dGTP as substrate after 15 mins by malachite green reagent-based assay | Homo sapiens | 8 | ALA4017528 | assay format | Scientific Literature | |
| 17. | ALA4037915 | B | Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli assessed as change in melting temperature at 1 mM after 2 mins by thermal shift assay | Homo sapiens | 6 | ALA4033791 | assay format | Scientific Literature | |
| 18. | ALA4037916 | B | Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetry assay | Homo sapiens | 1 | ALA4033791 | assay format | Scientific Literature | |
| 19. | ALA4037917 | B | Inhibition of human full length MTH1 using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPilight pyrophosphate-detection based assay | Homo sapiens | 34 | ALA4033791 | single protein format | Scientific Literature | |
| 20. | ALA4037927 | B | Inhibition of human full length MTH1 at 20 uM using 8-Oxo-2-dGTP as substrate preincubated for 15 mins followed substrate addition measured after 1 hr by PPilight pyrophosphate-detection based assay | Homo sapiens | 1 | ALA4033791 | single protein format | Scientific Literature |
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