# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA715570 | F | Agonist activity in rat at Metabotropic glutamate receptor 8 expressed in HEK293 cells | 1 | ALA1134758 | cell-based format | Scientific Literature | ||
2. | ALA715571 | F | Agonist activity in rat at mGlu8a receptor expressed in HEK293 cells | 2 | ALA1134758 | cell-based format | Scientific Literature | ||
3. | ALA872629 | F | Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells | Rattus norvegicus | 7 | ALA1148386 | cell-based format | Scientific Literature | |
4. | ALA715572 | F | Metabotropic glutamate receptor 8 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells; Not tested | 4 | ALA1148386 | cell-based format | Scientific Literature | ||
5. | ALA715573 | F | Metabotropic glutamate receptor 8 antagonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells | 1 | ALA1148386 | cell-based format | Scientific Literature | ||
6. | ALA715574 | F | Maximal effect obtained with 1 mM of the drug expressed as percent of maxiaml effect of glutamate in rat at mGlu8a receptor expressed in HEK293 cells | 2 | ALA1134758 | cell-based format | Scientific Literature | ||
7. | ALA863306 | B | Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells | Rattus norvegicus | 4 | ALA1148556 | cell-based format | Scientific Literature | |
8. | ALA912665 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells | Rattus norvegicus | 2 | ALA1137262 | cell-based format | Scientific Literature | |
9. | ALA912667 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells relative to glutamate | Rattus norvegicus | 1 | ALA1137262 | cell-based format | Scientific Literature | |
10. | ALA912669 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells | Rattus norvegicus | 1 | ALA1137262 | cell-based format | Scientific Literature | |
11. | ALA892223 | B | Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay | Rattus norvegicus | 5 | ALA1147898 | cell-based format | Scientific Literature | |
12. | ALA896250 | F | Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | Rattus norvegicus | 4 | ALA1148786 | cell-based format | Scientific Literature | |
13. | ALA948100 | B | Displacement of [3H]-L-AP4 from rat mGluR8 | Rattus norvegicus | 2 | ALA1142351 | single protein format | Scientific Literature | |
14. | ALA1110798 | F | Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader | Rattus norvegicus | 13 | ALA1156339 | cell-based format | Scientific Literature | |
15. | ALA1110799 | F | Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | Rattus norvegicus | 13 | ALA1156339 | cell-based format | Scientific Literature | |
16. | ALA1678456 | B | Positive allosteric modulation in rat mGluR8 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response at 10 uM | Rattus norvegicus | 1 | ALA1671788 | cell-based format | Scientific Literature | |
17. | ALA1696004 | B | Potentiation of rat mGluR8 receptor assessed as fold shift in glutamate concentration response curve at 10 uM relative to control | Rattus norvegicus | 1 | ALA1687701 | single protein format | Scientific Literature | |
18. | ALA1738560 | F | PUBCHEM_BIOASSAY: Modulation of the Metabotropic Glutamate Receptor mGluR4: Selectivity at mGluR8. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2437, AID2807] | Rattus norvegicus | 3 | ALA1201862 | assay format | PubChem BioAssays | |
19. | ALA1925100 | B | Positive allosteric modulator activity at rat mGlu8 receptor at 10 uM by thallium flux assay relative to glutamate | Rattus norvegicus | 3 | ALA1921795 | single protein format | Scientific Literature | |
20. | ALA1925107 | F | Antagonist activity at rat mGlu8 receptor at 10 uM by thallium flux assay | Rattus norvegicus | 3 | ALA1921795 | assay format | Scientific Literature |