# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA715570 | F | Agonist activity in rat at Metabotropic glutamate receptor 8 expressed in HEK293 cells | 1 | cell-based format | Scientific Literature | |||
2. | ALA715571 | F | Agonist activity in rat at mGlu8a receptor expressed in HEK293 cells | 2 | cell-based format | Scientific Literature | |||
3. | ALA872629 | F | Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells | Rattus norvegicus | 7 | cell-based format | Scientific Literature | ||
4. | ALA715572 | F | Metabotropic glutamate receptor 8 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells; Not tested | 4 | cell-based format | Scientific Literature | |||
5. | ALA715573 | F | Metabotropic glutamate receptor 8 antagonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells | 1 | cell-based format | Scientific Literature | |||
6. | ALA715574 | F | Maximal effect obtained with 1 mM of the drug expressed as percent of maxiaml effect of glutamate in rat at mGlu8a receptor expressed in HEK293 cells | 2 | cell-based format | Scientific Literature | |||
7. | ALA863306 | B | Displacement of [3H]LY341495 from rat mGluR8 expressed in BHK cells | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
8. | ALA912665 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
9. | ALA912667 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells relative to glutamate | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
10. | ALA912669 | F | Activity at rat mGluR8 receptor measured as intracellular calcium concentration in HEK293 cells | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
11. | ALA948100 | B | Displacement of [3H]-L-AP4 from rat mGluR8 | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
12. | ALA1925100 | B | Positive allosteric modulator activity at rat mGlu8 receptor at 10 uM by thallium flux assay relative to glutamate | Rattus norvegicus | 3 | single protein format | Scientific Literature | ||
13. | ALA1925107 | F | Antagonist activity at rat mGlu8 receptor at 10 uM by thallium flux assay | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
14. | ALA1925180 | B | Positive allosteric modulator activity at rat mGlu8 receptor at 10 uM by thallium flux assay | Rattus norvegicus | 1 | single protein format | Scientific Literature | ||
15. | ALA892223 | B | Displacement of [3H]LY341495 from rat recombinant mGluR8 expressed in BHK cells by SPA assay | Rattus norvegicus | 5 | cell-based format | Scientific Literature | ||
16. | ALA896250 | F | Agonist activity at rat mGluR8 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | Rattus norvegicus | 4 | cell-based format | Scientific Literature | ||
17. | ALA1110798 | F | Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader | Rattus norvegicus | 13 | cell-based format | Scientific Literature | ||
18. | ALA1110799 | F | Agonist activity at rat mGlu8 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular inositol phosphate accumulation after 1 hr by scintillation counting | Rattus norvegicus | 13 | cell-based format | Scientific Literature | ||
19. | ALA1678456 | B | Positive allosteric modulation in rat mGluR8 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response at 10 uM | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
20. | ALA1696004 | B | Potentiation of rat mGluR8 receptor assessed as fold shift in glutamate concentration response curve at 10 uM relative to control | Rattus norvegicus | 1 | single protein format | Scientific Literature |