# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA679573 | Binding | Inhibitory activity against Leishmania major Farnesyl diphosphate synthase; ND denotes not determined | Leishmania major | 5 | ALA1148279 | single protein format | Scientific Literature | |
2. | ALA679574 | Binding | Inhibitory activity against Leishmania major Farnesyl diphosphate synthase; ND means not determined | Leishmania major | 3 | ALA1148279 | single protein format | Scientific Literature | |
3. | ALA679575 | Binding | Inhibitory activity against Leishmania major Farnesyl-diphosphatesynthase (FPP synthase) | Leishmania major | 5 | ALA1148279 | single protein format | Scientific Literature | |
4. | ALA682839 | Binding | Compound was evaluated for concentration that caused 50% inhibition of yeast Farnesyltransferase (expressed as a GST fusion protein in Escherichia coli) | Saccharomyces cerevisiae | 3 | ALA1132076 | single protein format | Scientific Literature | |
5. | ALA844994 | Binding | Inhibition of squalene synthase from human hepatoma cells (HepG2) | Homo sapiens | 15 | ALA1135616 | assay format | Scientific Literature | |
6. | ALA844995 | Binding | Inhibitory activity against squalene synthase derived from human hepatoma cells (HepG2) | 2 | ALA1135616 | assay format | Scientific Literature | ||
7. | ALA844996 | Binding | Concentration required for 50% inhibitory activity against squalene synthase derived from human hepatoma cells (HepG2) | 1 | ALA1135616 | assay format | Scientific Literature | ||
8. | ALA869977 | Binding | Inhibitory activity against Trypanosoma cruzi glycosomal squalene synthase | Trypanosoma cruzi | 1 | ALA1149382 | single protein format | Scientific Literature | |
9. | ALA1244159 | Binding | Inhibition of squalene synthase in human Jurkat JA16 cells assessed as cholesterol level at 5 uM after 14 to 18 hrs by fluorescence correlation spectroscopy relative to control | Homo sapiens | 1 | ALA1240339 | cell-based format | Scientific Literature | |
10. | ALA1244173 | Binding | Inhibition of squalene synthase in human Jurkat JA16 cells assessed as cholesterol level at 25 uM after 14 to 18 hrs by fluorescence correlation spectroscopy relative to control | Homo sapiens | 1 | ALA1240339 | cell-based format | Scientific Literature | |
11. | ALA1244179 | Binding | Inhibition of squalene synthase in human Jurkat JA16 cells assessed as lateral diffusion of the outer membrane leaflet-linked GFP-AKt PH nanodomain at 5 uM after 14 to 18 hrs by fluorescence correlation spectroscopy | Homo sapiens | 1 | ALA1240339 | cell-based format | Scientific Literature | |
12. | ALA1244182 | Binding | Inhibition of squalene synthase in human Jurkat JA16 cells assessed as lateral diffusion of the outer membrane leaflet-linked Lck(1-12)-GFP nanodomain at 5 uM after 14 to 18 hrs by fluorescence correlation spectroscopy | Homo sapiens | 1 | ALA1240339 | cell-based format | Scientific Literature | |
13. | ALA1763976 | Binding | Inhibition of squalene synthase assessed as conversion of [3H]farnesyl phosphate to [3H]squalene after 10 mins by scintillation counting | 20 | ALA1759907 | single protein format | Scientific Literature | ||
14. | ALA1781817 | Binding | Inhibition of recombinant squalene synthase assessed as conversion of trans,trans-[1-3H]farnesyl pyrophosphate to [3H]squalene after 10 mins by liquid scintillation counting | 9 | ALA1777787 | single protein format | Scientific Literature | ||
15. | ALA808215 | Binding | Inhibitory activity against HepG2 Squalene Synthase (SQS) | 10 | ALA1151488 | single protein format | Scientific Literature | ||
16. | ALA809116 | Binding | Inhibition of Squalene Synthase | 5 | ALA1130535 | single protein format | Scientific Literature | ||
17. | ALA809142 | Binding | Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQS | Candida albicans | 7 | ALA1127350 | microsome format | Scientific Literature | |
18. | ALA809143 | Binding | Compound was tested for in vitro inhibitory activity against Candida albicans 2005E microsomal SQS; Not tested | Candida albicans | 7 | ALA1127350 | microsome format | Scientific Literature | |
19. | ALA809144 | Binding | In vitro inhibitory activity against Candida albicans squalene synthase | Candida albicans | 5 | ALA1127965 | single protein format | Scientific Literature | |
20. | ALA873254 | Binding | Inhibition of Candida albicans squalene synthase(SQS) | Candida albicans | 17 | ALA1151052 | single protein format | Scientific Literature |