# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1794543 | F | PUBCHEM_BIOASSAY: Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2239, AID2258, AID2287] | 5 | ALA1201862 | cell-based format | PubChem BioAssays | ||
2. | ALA1794583 | F | PUBCHEM_BIOASSAY: Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2239, AID2258, AID2287] | 4 | ALA1201862 | cell-based format | PubChem BioAssays | ||
3. | ALA2071939 | B | Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay relative to control | Homo sapiens | 1 | ALA2069205 | cell-based format | Scientific Literature | |
4. | ALA2071943 | B | Activation of KCNQ4 channel expressed in CHO cells assessed as depolarization-induced thallium influx up to 30 uM after 3 mins by patch clamp assay relative to control | Homo sapiens | 1 | ALA2069205 | cell-based format | Scientific Literature | |
5. | ALA2169526 | F | Antagonist activity at KCNQ4 expressed in CHO cells incubated for 3 mins by automated patch clamp assay | 1 | ALA2163245 | cell-based format | Scientific Literature | ||
6. | ALA2327426 | B | Positive modulatory activity at voltage-gated K channel 7.4 (unknown origin) | Homo sapiens | 1 | ALA2321869 | single protein format | Scientific Literature | |
7. | ALA3624289 | B | Activation of human Kv7.4 expressed in CHOK1 cells | Homo sapiens | 1 | ALA3621090 | cell-based format | Scientific Literature | |
8. | ALA3624296 | B | Activation of human Kv7.4 expressed in CHOK1 cells assessed as increase in current amplitude relative to control | Homo sapiens | 1 | ALA3621090 | cell-based format | Scientific Literature | |
9. | ALA4260482 | B | Activation of human Kv7.4 by patch clamp method | Homo sapiens | 7 | ALA4257569 | assay format | Scientific Literature | |
10. | ALA4385383 | B | Activity at human KCNQ4 expressed in CHOK1 cells assessed as ratio of amplitude of outward current in presence of test compound to amplitude of outward current in absence of test compound at 10 uM at -10 mV by whole cell patch clamp assay | Homo sapiens | 28 | ALA4382285 | cell-based format | Scientific Literature | |
11. | ALA4385386 | B | Activation of human homomeric KCNQ4 expressed in CHOK1 cells at -10 mV by whole cell patch clamp assay | Homo sapiens | 1 | ALA4382285 | cell-based format | Scientific Literature | |
12. | ALA4385394 | B | Activity at human KCNQ4 expressed in CHOK1 cells assessed as ratio of amplitude of outward current in presence of test compound to amplitude of outward current in absence of test compound at 10 uM at +60 mV by whole cell patch clamp assay | Homo sapiens | 1 | ALA4382285 | cell-based format | Scientific Literature | |
13. | ALA4385396 | B | Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay | Homo sapiens | 4 | ALA4382285 | cell-based format | Scientific Literature | |
14. | ALA4385404 | B | Effect on voltage-dependent activation of human KCNQ4 expressed in CHOK1 cells assessed as negative shift in current activation curve at 10 uM by whole cell patch clamp assay | Homo sapiens | 3 | ALA4382285 | cell-based format | Scientific Literature | |
15. | ALA4385406 | B | Channel opening activity at human KCNQ4 expressed in CHOK1 cells at 10 uM at -60 mV by whole cell patch clamp assay | Homo sapiens | 1 | ALA4382285 | cell-based format | Scientific Literature | |
16. | ALA4403827 | A | Activation of human Kv7.4 expressed in CHO cells assessed as delta V at 10 uM by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
17. | ALA4403831 | A | Activation of human Kv7.4 expressed in CHO cells assessed as increase in channel current amplitude by whole cell patch clamp electrophysiology assay | Homo sapiens | 3 | ALA4402547 | cell-based format | Scientific Literature | |
18. | ALA4434270 | B | Agonist activity at human Kv7.4 expressed in HEK293 cells assessed as drug concentration that doubles the conductance at voltage leading to 15% channel activation at holding potential of at -80 mV by whole cell patch clamp electrophysiology assay | Homo sapiens | 22 | ALA4433246 | cell-based format | Scientific Literature | |
19. | ALA5116583 | B | Agonist activity at Kv7.4 (unknown origin) expressed in CHO cells co-expressing GFP | Homo sapiens | 4 | ALA5113435 | cell-based format | Scientific Literature | |
20. | ALA5125933 | B | Agonist activity at human KCNQ4 channel expressed in CHO cells assessed as increase in outward current by patch clamp electrophysiology method | Homo sapiens | 1 | ALA5120947 | cell-based format | Scientific Literature |