| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA684581 | B | Inhibition of human granzyme A | 36 | single protein format | Scientific Literature | |||
| 2. | ALA4344609 | B | Substrate activity at Granzyme A (unknown origin) expressed in Pichia pastoris incubated for 30 mins by fluorescence based assay | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 3. | ALA4344613 | B | Inhibition of Granzyme A (unknown origin) expressed in Pichia pastoris assessed as second- order inhibition rate constant (Kobs/I ratio) pre-incubated with SK15 substrate for 15 mins before enzyme addition by spectrofluorometry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 4. | ALA4344614 | B | Inhibition of Granzyme A (unknown origin) expressed in Pichia pastoris using SK15 substrate by spectrofluorometry relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 5. | ALA4344620 | B | Binding affinity to Granzyme A (unknown origin) expressed in Pichia pastoris assessed as appearance of fluorescent 35 kDa species at enzyme to probe ratio was 1:1 incubated for 5 mins by SDS-PAGE based in-gel detection method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4344621 | B | Binding affinity to Granzyme A (unknown origin) expressed in Pichia pastoris assessed as minimum concentration needed for GrA labeling at enzyme to probe ratio was 1:1 incubated for 5 to 30 mins by SDS-PAGE based in-gel detection method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4344622 | B | Binding affinity to Granzyme A active form (unknown origin) expressed in Pichia pastoris by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4344623 | B | Binding affinity to Granzyme A zymogen form (unknown origin) expressed in Pichia pastoris by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA4344624 | B | Binding affinity to Granzyme A active form (unknown origin) expressed in Pichia pastoris at 500 nM in presence of 1 uM methyl 4-[(3S)-3-[[2-[(2S)-2-[(1-diphenoxyphosphoryl-4-guanidinobutyl)carbamoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-2-oxoethyl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxobutanoate by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4344625 | B | Binding affinity to Granzyme A zymogen form (unknown origin) expressed in Pichia pastoris at 500 nM in presence of 1 uM compound 3 by Western blot analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4344626 | B | Binding affinity to Granzyme A in human NK92 cells at 250 nM to 2 uM incubated for 1 hr by SDS-PAGE based in-gel detection assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4344630 | B | Binding affinity to Granzyme A in human NK92 cells at 1 uM measured 30 mins to 2 hrs post dose by SDS-PAGE analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4344631 | B | Binding affinity to Granzyme A in human NK92 cells at 1 uM treated 1 hr after GrA covalent inhibitor methyl 4-[(3S)-3-[[2-[(2S)-2-[(1-diphenoxyphosphoryl-4-guanidinobutyl)carbamoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-2-oxoethyl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxobutanoate dosing and measured 30 mins to 2 hrs post dose by SDS-PAGE analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA5241649 | B | Inhibition of human recombinant GzmA assessed as Kobs/[I] | Homo sapiens | 1 | single protein format | Scientific Literature |
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