| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA660380 | A | Inhibitory effect on human recombinant liver cytochrome P450 2C18 expressed in yeast strain | 24 | assay format | Scientific Literature | |||
| 2. | ALA3541788 | A | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA3538130 | A | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA3539709 | A | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA3539720 | A | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated clozapine-N-oxide metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA3537637 | A | Activity of recombinant human CYP2C18 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism measured as compound remaining after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA3537638 | A | Activity of recombinant human CYP2C18 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 8. | ALA3536203 | A | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated cyanide adduct formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis in presence of KCN | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3535091 | A | Activity of human recombinant CYP2C18 assessed as glutathione conjugate formation at 50 uM in presence of NADPH and glutathione by LC-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3533010 | A | Activity at human recombinant CYP2C18 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation at 5 to 100 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA3532129 | A | Activity of human recombinant CYP2C18 assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3529575 | A | Activity of human recombinant CYP2C18 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA3530226 | A | Activity of human recombinant CYP2C18 assessed as metabolite formation at 50 uM in presence of NADPH by LC-MS/MS method | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA3864044 | A | Drug metabolism in Escherichia coli membranes expressing recombinant CYP2C18 (unknown origin) co-expressed with human NADPH-CPR/bacterial GroEL/GroES assessed as CYP2C18-mediated R-(+)- N-((1-hydroxy-1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4-(2-hydroxypropan-2-yl)furan-2-sulfonamide formation at 10 to 100 uM after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell membrane format | Scientific Literature | ||
| 15. | ALA4675245 | A | Inhibition of human CYP2C18 expressed in Sacchrosomes by fluorescence based assay | Homo sapiens | 2 | assay format | Scientific Literature |
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