| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3509251 | A | Enzyme kinetics constant (Km value) for CYP4A11 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 2. | ALA3509260 | A | Enzyme kinetics constant (Vmax value) for CYP4A11 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 3. | ALA3509269 | A | Metabolic clearance (ul.min.nmol-1 CYP) of aliskiren hemifumarate for CYP4A11 was determined in human liver microsome incubated with [14C]SPP100 hemifumarate | Homo sapiens | 1 | microsome format | FDA Approval Packages | ||
| 4. | ALA3538476 | A | Activity of recombinant human CYP4A11 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism measured as compound remaining after 1 hr by LC-MS analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA3538477 | A | Activity of recombinant human CYP4A11 expressed in Escherichia coli JM109 co-expressing P450 reductase assessed as enzyme-mediated drug metabolism treated with LBH589 measured after 1 hr by LC-MS analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 6. | ALA3536228 | A | Drug metabolism in human recombinant CYP4A11 mediated oxidative metabolism at 10 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA3533015 | A | Activity at human recombinant CYP4A11 expressed in baculovirus-infected BTI-TN-5B1-4 insect cell microsomes assessed as metabolite formation at 5 to 100 uM after 30 mins by HPLC-RA analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3535404 | A | Apparent intrinsic clearance assessed as ratio of Vmax to Km for human recombinant CYP4A11-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA3532134 | A | Activity of human recombinant CYP4A11 assessed as enzyme-mediated drug metabolism treated with 25 uM vorapaxar after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA3528381 | A | Drug metabolism assessed as human recombinant CYP4A11-mediated 17-hydroexemestane formation at 10 uM after 10 mins by Michaelis-Menten saturation curve analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA3528397 | A | Drug metabolism assessed as human recombinant CYP4A11-mediated 17-hydroexemestane formation rate per pmol of enzyme at 10 uM after 10 mins | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA3529775 | A | Activity of human recombinant CYP4A11 assessed as enzyme-mediated 2-hydroxyethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate formation at 25 uM after 120 mins by LC-MS/MS analysis in presence of NADPH | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4406421 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells at 30 uM using Luc-4A as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4406427 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells using Luc-4A as substrate after 10 mins in presence of NADPH by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4406428 | A | Ratio of IC50 for inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells using Luc-4A as substrate after 10 mins in presence of NADPH to IC50 for inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells using Luc-4A as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4406434 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus infected insect cells using Luc-4A as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by P450-glo luciferase based luminescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA5113119 | B | Inhibition of human recombinant CYP4A11 using Luciferin-4A as substrate incubated for 60 mins in presence of NADPH regenerating system by luminescence based assay | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 18. | ALA5115434 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus-infected insect cells in presence of arachidonic acid and NADPH incubated for 15 mins by jump-dilution assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA5115435 | A | Inhibition of recombinant human CYP4A11 expressed in baculovirus-infected insect cells at 50 uM incubated for 15 mins in presence of arachidonic acid and NADPH by jump-dilution assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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