# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3625051 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene at 10 uM incubated for 30 mins by liquid scintillation counting method | Rattus norvegicus | 14 | ALA3621067 | assay format | Scientific Literature | |
2. | ALA3625052 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene at 50 uM incubated for 30 mins by liquid scintillation counting | Rattus norvegicus | 3 | ALA3621067 | assay format | Scientific Literature | |
3. | ALA3625056 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 30 mins by liquid scintillation counting | Rattus norvegicus | 6 | ALA3621067 | assay format | Scientific Literature | |
4. | ALA677589 | Binding | Inhibitory concentration was measured towards partially purified FPTase enzyme from rat brain using a scintillation proximity assay method in vitro | 2 | ALA1153664 | assay format | Scientific Literature | ||
5. | ALA677590 | Binding | Inhibitory concentration was measured towards partially purified FPTase enzyme from rat brain using a scintillation proximity assay method in vitro at dose of 100 uM | 1 | ALA1153664 | assay format | Scientific Literature | ||
6. | ALA1104441 | Binding | Inhibition of squalene synthase in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 1 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
7. | ALA1104444 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as conversion of [1-3H]FPP to [3H]squalene level after 60 mins by liquid scintillation counting | Rattus norvegicus | 5 | ALA1156999 | microsome format | Scientific Literature | |
8. | ALA1104452 | Binding | Inhibition of squalene synthase in rat liver S10 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 10 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
9. | ALA1104453 | Binding | Inhibition of squalene synthase in rat liver S100 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 1 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
10. | ALA1104454 | Binding | Inhibition of squalene synthase in rat liver S100 supernatant assessed as conversion of (R,S)-[2-14C]mevalonic acid to [14C]squalene at 10 uM after 60 mins | Rattus norvegicus | 4 | ALA1156999 | assay format | Scientific Literature | |
11. | ALA1273704 | Binding | Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation counting | Rattus norvegicus | 13 | ALA1268937 | microsome format | Scientific Literature | |
12. | ALA1820080 | Binding | Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillation counting | Rattus norvegicus | 23 | ALA1817583 | single protein format | Scientific Literature | |
13. | ALA811514 | Binding | Inhibitory activity against squalene synthase in rat liver squalene synthase (RLSS) enzyme assay | 7 | ALA1127923 | assay format | Scientific Literature | ||
14. | ALA811515 | Binding | Effective dose to inhibit rat liver microsomal Squalene Synthase was determined by intravenous administration | 3 | ALA1128430 | assay format | Scientific Literature | ||
15. | ALA813342 | Binding | Effective dose to inhibit rat liver microsomal Squalene Synthase was determined by peroral administration | 1 | ALA1128430 | assay format | Scientific Literature | ||
16. | ALA813343 | Binding | Effective dose to inhibit rat liver microsomal Squalene Synthase was determined by peroral administration at a dose of 30 mg/kg; In active | 1 | ALA1128430 | organism-based format | Scientific Literature | ||
17. | ALA813344 | Binding | Effective dose to inhibit rat liver microsomal Squalene synthase was determined by intravenous administration | 1 | ALA1128430 | assay format | Scientific Literature | ||
18. | ALA883012 | Functional | Effective dose to inhibit rat liver microsomal Squalene synthase was determined by intravenous administration | 2 | ALA1128430 | organism-based format | Scientific Literature | ||
19. | ALA813345 | Functional | Effective dose to inhibit rat liver microsomal Squalene synthase was determined by peroral administration | 2 | ALA1128430 | organism-based format | Scientific Literature | ||
20. | ALA813346 | Binding | Effective dose to inhibit rat liver microsomal Squalene synthase was determined by peroral administration at a dose of 15 mg/kg; inactive | 1 | ALA1128430 | organism-based format | Scientific Literature |