# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA857426 | B | Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells | 2 | ALA1123056 | cell-based format | Scientific Literature | ||
2. | ALA770785 | B | Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate | Oryctolagus cuniculus | 3 | ALA1129767 | assay format | Scientific Literature | |
3. | ALA770786 | B | Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes | Oryctolagus cuniculus | 2 | ALA1123056 | cell-based format | Scientific Literature | |
4. | ALA797543 | B | Relative ability of compound to activate Ribonuclease L to cleave poly(U)p[32P]Cp, compared to that of 2-5A standard (Crel=1) | 3 | ALA1133042 | single protein format | Scientific Literature | ||
5. | ALA797544 | B | Relative ability of compound to activate Ribonuclease L to cleave poly(U)p[32P]Cp, compared to that of 2-5A standard (Crel=1); No cleavage detected | 2 | ALA1133042 | single protein format | Scientific Literature | ||
6. | ALA797545 | B | Relative binding affinity of compound to human recombinant Ribonuclease L, compared to that of 2-5A standard (Crel=1) | 3 | ALA1133042 | single protein format | Scientific Literature | ||
7. | ALA797546 | B | Relative binding affinity of compound to human recombinant Ribonuclease L, compared to that of 2-5A standard (Crel=1); No binding detected | 2 | ALA1133042 | single protein format | Scientific Literature | ||
8. | ALA795061 | B | Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7 | 7 | ALA1133074 | single protein format | Scientific Literature | ||
9. | ALA795208 | B | Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p | 7 | ALA1133074 | single protein format | Scientific Literature | ||
10. | ALA878861 | B | Binding affinity of compound to human recombinant Ribonuclease L was evaluated | 1 | ALA1133042 | single protein format | Scientific Literature | ||
11. | ALA795209 | B | Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L | 7 | ALA1133074 | single protein format | Scientific Literature | ||
12. | ALA800845 | B | Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluated | 1 | ALA1133042 | single protein format | Scientific Literature | ||
13. | ALA929125 | B | Displacement of 5'-phosphorylated, 2',5'-oligoadenylate from human recombinant RNase L assessed as decrease in resonance by surface plasma resonance | Homo sapiens | 3 | ALA1142230 | single protein format | Scientific Literature | |
14. | ALA929126 | B | Activation of human recombinant RNaseL at 40 uM assessed as cleavage of FRET RNA probe | Homo sapiens | 2 | ALA1142230 | single protein format | Scientific Literature | |
15. | ALA929127 | B | Activation of human recombinant Rnase L assessed as cleavage of FRET RNA probe | Homo sapiens | 12 | ALA1142230 | single protein format | Scientific Literature | |
16. | ALA929128 | B | Induction of dimerization of human RNaseL at 0.06 to 0.25 uM assessed by Western blotting | Homo sapiens | 2 | ALA1142230 | single protein format | Scientific Literature | |
17. | ALA929129 | B | Induction of dimerization of human RNaseL at 3 to 12 uM assessed by Western blotting | Homo sapiens | 2 | ALA1142230 | single protein format | Scientific Literature | |
18. | ALA929139 | B | Activation of human recombinant RNase L assessed as cleavage of FRET RNA probe at 15 mins | Homo sapiens | 1 | ALA1142230 | single protein format | Scientific Literature | |
19. | ALA929140 | B | Activation of human recombinant RNase L assessed as cleavage of FRET RNA probe at until 60 to 90 mins | Homo sapiens | 2 | ALA1142230 | single protein format | Scientific Literature | |
20. | ALA929141 | B | Activation of human recombinant RNase L assessed as cleavage of p32-labelled RNA molecule at 25 uM after 30 mins | Homo sapiens | 3 | ALA1142230 | single protein format | Scientific Literature |