| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA845244 | B | Compound was evaluated for Michaelis-Menten constant (Km) in a reaction with tryptophan indole-lyase (tryptophanase) from Escherichia coli | Escherichia coli | 4 | ALA1126004 | single protein format | Scientific Literature | |
| 2. | ALA845245 | B | Compound was evaluated for relative maximum velocity (Vmax) in a reaction with tryptophan indole-lyase (tryptophanase) from Escherichia coli | Escherichia coli | 4 | ALA1126004 | single protein format | Scientific Literature | |
| 3. | ALA1043001 | B | Inhibition of tryptophan 2,3-dioxygenase | 1 | ALA1154769 | single protein format | Scientific Literature | ||
| 4. | ALA1043002 | B | Inhibition of tryptophan 2,3-dioxygenase by cell-based assay | 1 | ALA1154769 | cell-based format | Scientific Literature | ||
| 5. | ALA1817449 | B | Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine after 30 mins by Michaelis-Menten steady state analysis | Homo sapiens | 4 | ALA1811872 | assay format | Scientific Literature | |
| 6. | ALA1816040 | B | Activity of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formylkynurenine into kynurenine per mg of protein after 30 mins by Michaelis-Menten steady state analysis | Homo sapiens | 1 | ALA1811872 | assay format | Scientific Literature | |
| 7. | ALA2044105 | B | Inhibition of liver TDO | 1 | ALA2040834 | assay format | Scientific Literature | ||
| 8. | ALA2044106 | B | Inhibition of human purified TDO assessed as formation of kynurenine from N-formylkynurenine preincubated for 10 mins measured after 5 to 20 mins by discontinuous colorimetric method | Homo sapiens | 4 | ALA2040834 | single protein format | Scientific Literature | |
| 9. | ALA2044107 | B | Competitive inhibition of human purified TDO by Henri-Michaelis-Menten equation analysis | Homo sapiens | 1 | ALA2040834 | single protein format | Scientific Literature | |
| 10. | ALA2044108 | B | Inhibition of human purified TDO assessed as initial rate of L-Trp oxidation at 100 uM of substrate concentration | Homo sapiens | 1 | ALA2040834 | single protein format | Scientific Literature | |
| 11. | ALA2150233 | B | Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysis | Homo sapiens | 31 | ALA2146377 | cell-based format | Scientific Literature | |
| 12. | ALA3578682 | B | Activity of 1 uM recombinant human TDO assessed as substrate consumption at 100 uM at 37 degC at pH 7.5 after 1 hr by HPLC with fluorescence detection method | Homo sapiens | 4 | ALA3576814 | single protein format | Scientific Literature | |
| 13. | ALA3578683 | B | Activity of 10 uM recombinant human TDO assessed as substrate consumption at 100 uM at 37 degC at pH 7.5 after 1 hr by HPLC with fluorescence detection method | Homo sapiens | 4 | ALA3576814 | single protein format | Scientific Literature | |
| 14. | ALA3630805 | B | Inhibition of TDO (unknown origin) | Homo sapiens | 3 | ALA3627665 | single protein format | Scientific Literature | |
| 15. | ALA3630807 | B | Inhibition of human TDO | Homo sapiens | 2 | ALA3627665 | single protein format | Scientific Literature | |
| 16. | ALA3631085 | B | Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assay | Homo sapiens | 20 | ALA3627649 | assay format | Scientific Literature | |
| 17. | ALA3631100 | B | Binding affinity to recombinant human TDO assessed as shift in Soret signal at 2 mM by UV-visible spectra analysis | Homo sapiens | 1 | ALA3627649 | single protein format | Scientific Literature | |
| 18. | ALA3867385 | B | Inhibition of N-terminal 6xHis-tagged human TDO expressed in Escherichia cli Rosetta (DE3) pLysS using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by spectrophotometric analysis | Homo sapiens | 13 | ALA3865851 | assay format | Scientific Literature | |
| 19. | ALA3867386 | B | Inhibition of N-terminus 6xHis-tagged human TDO expressed in expressed in Escherichia coli Rosetta (DE3) pLysS using L-tryptophan as substrate preincubated for 1 hr measured after 15 mins in presence of bovine liver and methylene blue by HPLC analysis | Homo sapiens | 13 | ALA3865851 | assay format | Scientific Literature | |
| 20. | ALA3871117 | B | Inhibition of TDO2 in human A172 cells assessed as kynurenine formation after overnight incubation | Homo sapiens | 6 | ALA3870353 | cell-based format | Scientific Literature |
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