# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA702028 | Binding | Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in Kidney from Gerbils after injecting perorally | Gerbillinae | 4 | ALA1130431 | tissue-based format | Scientific Literature | |
2. | ALA702029 | Binding | Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in Liver from Gerbils after injecting perorally | Gerbillinae | 4 | ALA1130431 | tissue-based format | Scientific Literature | |
3. | ALA702030 | Binding | Compound was evaluated for ex vivo inhibition of Kynurenine 3-hydroxylase activity in brain from Gerbils after injecting perorally | Gerbillinae | 4 | ALA1130431 | tissue-based format | Scientific Literature | |
4. | ALA702031 | Binding | Percent inhibition of kynurenine 3-hydroxylase, when 30 umol/kg of compound was administered orally in gerbil kidney and liver | Gerbillinae | 1 | ALA1130431 | assay format | Scientific Literature | |
5. | ALA702032 | Binding | Percent inhibition of kynurenine 3-hydroxylase, when 30 umol/kg of compound was administered orally in gerbils | Gerbillinae | 1 | ALA1130431 | single protein format | Scientific Literature | |
6. | ALA881158 | Binding | Compound was evaluated for inhibition of human recombinant KYN 3-OHase | 2 | ALA1130635 | single protein format | Scientific Literature | ||
7. | ALA842820 | Binding | Compound was evaluated for inhibition of human recombinant KYN 3-OHase. | 1 | ALA1130635 | single protein format | Scientific Literature | ||
8. | ALA1219092 | Binding | Inhibition of kynurenine 3-monooxygenase in human prefrontal cortex homogenates at 100 uM | Homo sapiens | 1 | ALA1212922 | tissue-based format | Scientific Literature | |
9. | ALA3413142 | Binding | Inhibition of human KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Homo sapiens | 64 | ALA3407478 | single protein format | Scientific Literature | |
10. | ALA3413143 | Binding | Inhibition of human KMO transfected in CHO cells assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis | Homo sapiens | 64 | ALA3407478 | cell-based format | Scientific Literature | |
11. | ALA3413308 | Binding | Inhibition of KMO in human PBMC | Homo sapiens | 5 | ALA3407478 | single protein format | Scientific Literature | |
12. | ALA3414283 | Binding | Inhibition of KMO (unknown origin) | Homo sapiens | 2 | ALA3407478 | single protein format | Scientific Literature | |
13. | ALA3536664 | ADME | Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis | Homo sapiens | 4 | ALA3526063 | single protein format | Scientific Literature | |
14. | ALA3536667 | ADME | Inhibition of human KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analysis in presence of 3 mg/ml plasma protein | Homo sapiens | 1 | ALA3526063 | single protein format | Scientific Literature | |
15. | ALA3536674 | ADME | Inhibition of KMO (unknown origin) | Homo sapiens | 1 | ALA3526063 | single protein format | Scientific Literature | |
16. | ALA3630810 | Binding | Inhibition of human KMO | Homo sapiens | 4 | ALA3627665 | single protein format | Scientific Literature | |
17. | ALA3636891 | Binding | Inhibition of kynurenine monooxygenase (unknown origin) by MS rapidfire assay | Homo sapiens | 5 | ALA3632551 | single protein format | Scientific Literature | |
18. | ALA3871819 | Binding | Inhibition of human KMO | Homo sapiens | 51 | ALA3871283 | single protein format | Scientific Literature | |
19. | ALA4011242 | Binding | Inhibition of KMO (unknown origin) | Homo sapiens | 1 | ALA4007495 | single protein format | Scientific Literature | |
20. | ALA4012392 | Binding | Inhibition of recombinant full-length human N-terminal GST tagged KMO expressed in baculovirus infected Sf9 insect cell membranes using L-kynurenine as substrate measured after 2 hrs in presence of NADPH by RapidFire mass spectrometric method | Homo sapiens | 33 | ALA4011608 | assay format | Scientific Literature |