# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3428702 | Binding | Inhibition of SHP2 (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysis | Homo sapiens | 1 | ALA3425498 | single protein format | Scientific Literature | |
2. | ALA3430026 | Binding | Inhibition of human recombinant SHP2 PTP domain (225 to 541) using pNPP as substrate | Homo sapiens | 1 | ALA3425500 | single protein format | Scientific Literature | |
3. | ALA3430027 | Binding | Inhibition of SHP2 catalytic domain (262 to 528) (unknown origin) expressed in Escherichia coli BL21 (DE3) using pNPP as substrate by spectrophotometric analysis | Homo sapiens | 1 | ALA3425500 | assay format | Scientific Literature | |
4. | ALA3430028 | Binding | Inhibition of human recombinant GST-tagged SHP2 (205 to 593) expressed in Escherichia coli DH5-alpha using DiFMUP as substrate after 30 mins by fluorescence assay | Homo sapiens | 1 | ALA3425500 | assay format | Scientific Literature | |
5. | ALA3592741 | Binding | Binding affinity to SHP2 (unknown origin) | Homo sapiens | 1 | ALA3588828 | single protein format | Scientific Literature | |
6. | ALA3595309 | Binding | Inhibition of SHP2 (unknown origin) using pNPP as substrate | Homo sapiens | 1 | ALA3593243 | single protein format | Scientific Literature | |
7. | ALA3595310 | Binding | Inhibition of SHP2 (unknown origin) using pNPP as substrate at 25 uM relative to control | Homo sapiens | 3 | ALA3593243 | single protein format | Scientific Literature | |
8. | ALA3599426 | Binding | Inhibition of human SHP2 using pNPP substrate by spectrophotometry | Homo sapiens | 1 | ALA3596177 | single protein format | Scientific Literature | |
9. | ALA3611553 | Binding | Inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate after 10 mins by spectrophotometer analysis | Homo sapiens | 4 | ALA3608232 | single protein format | Scientific Literature | |
10. | ALA3611569 | Binding | Competitive inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate Lineweaver-Burk plot analysis | Homo sapiens | 2 | ALA3608232 | single protein format | Scientific Literature | |
11. | ALA3611584 | Binding | Inhibition of phosphatase activity of SHP2 (unknown origin) using pNPP as a substrate at 50 uM after 10 mins by spectrophotometer analysis | Homo sapiens | 4 | ALA3608232 | single protein format | Scientific Literature | |
12. | ALA3611701 | Binding | Ratio of cefsulodin IC50 to compound IC50 for phosphatase activity of SHP2 (unknown origin) | Homo sapiens | 3 | ALA3608232 | single protein format | Scientific Literature | |
13. | ALA3611706 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of EGF-induced ERK1/2 activation at 10 uM after 60 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
14. | ALA3611707 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of EGF-induced ERK1/2 activation at 20 uM after 60 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
15. | ALA3611708 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of EGF-induced ERK1/2 activation at 40 uM after 60 mins relative to control | Homo sapiens | 2 | ALA3608232 | cell-based format | Scientific Literature | |
16. | ALA3611709 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of PMA-induced ERK1/2 activation at 20 uM after 10 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
17. | ALA3611710 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of PMA-induced ERK1/2 activation at 40 uM after 10 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
18. | ALA3611711 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of PMA-induced ERK1/2 activation at 20 uM after 30 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
19. | ALA3611712 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of PMA-induced ERK1/2 activation at 40 uM after 30 mins relative to control | Homo sapiens | 1 | ALA3608232 | cell-based format | Scientific Literature | |
20. | ALA3611713 | Binding | Inhibition of SHP2 in human NCI-H1975 cells assessed as reduction of EGF-induced paxillin phosphorylation at Y118 at 40 uM after 60 mins relative to control | Homo sapiens | 2 | ALA3608232 | cell-based format | Scientific Literature |