# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA661349 | F | Percent activation of wild type CFTR dependent efflux was determined by measuring the rate of iodide [125I]- efflux from transfected CHO cells | 26 | cell-based format | Scientific Literature | |||
2. | ALA661350 | F | Percent activation of wild type CFTR dependent efflux was determined by measuring the rate of iodide [125I]- efflux from transfected CHO cells; ND = not determined | 2 | cell-based format | Scientific Literature | |||
3. | ALA665292 | F | Half-Maximal effective concentration of compound required to stimulate of G551D-CFTR activity in the presence of 10 uM Fsk | 8 | assay format | Scientific Literature | |||
4. | ALA665293 | F | Half-Maximal effective concentration of compound required to stimulate of wild type-CFTR activity in the presence of 10 uM Fsk | 8 | assay format | Scientific Literature | |||
5. | ALA833631 | F | Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTR | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
6. | ALA853576 | F | Potentiation of deltaF508 mutated CFTR dependent iodide influx at 0.1 uM | 1 | assay format | Scientific Literature | |||
7. | ALA2050117 | B | Inhibition of CFTR in forskolin-stimulated human epithelial cells at 30 uM | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA1817223 | B | Activity at CFTR F508 deletion mutant expressed in forskolin-stimulated FRT cells assessed as maximal increase in iodine influx measured as YFP quenching rate after 24 hrs by fluorescence assay | 23 | cell-based format | Scientific Literature | |||
9. | ALA1817225 | B | Activity at CFTR F508 deletion mutant expressed in forskolin-stimulated FRT cells assessed as maximal increase in iodine influx measured as YFP quenching rate after 24 hrs by fluorescence assay relative to nifedipine | 1 | cell-based format | Scientific Literature | |||
10. | ALA1817226 | B | Activity at CFTR F508 deletion mutant expressed in forskolin-stimulated FRT cells assessed as maximal increase in iodine influx measured as YFP quenching rate up to 20 uM after 24 hrs by fluorescence assay | 14 | cell-based format | Scientific Literature | |||
11. | ALA1817227 | B | Activity at CFTR F508 deletion mutant expressed in forskolin-stimulated FRT cells assessed as maximal increase in iodine influx measured as YFP quenching rate at 0.2 uM after 24 hrs by fluorescence assay | 32 | cell-based format | Scientific Literature | |||
12. | ALA1832634 | B | Inhibition of CFTR | 1 | single protein format | Scientific Literature | |||
13. | ALA1832641 | F | Inhibition of human wild-type CFTR expressed in FRT cells coexpressing YFP-H148Q assessed as inhibition of cAMP agonist-induced iodide influx after 45 mins by fluorescence plate-reader analysis | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
14. | ALA1832642 | B | Inhibition of human wild-type CFTR expressed in FRT cells assessed as inhibition of forskolin-induced short-circuit current by voltage clamp electrophysiology assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
15. | ALA944926 | B | Binding affinity to GST tagged human CFTR PDZ2 domain | Homo sapiens | 5 | single protein format | Scientific Literature | ||
16. | ALA944928 | B | Binding affinity to GST tagged human CFTR PDZ2 domain upto 300 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA2073574 | B | Corrector activity at human CFTR deltaF508 mutant expressed in FRT cells stimulated forskolin and potentiator genistein with assessed as iodide influx incubated for 24 hrs | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
18. | ALA1941776 | B | Modulation of C-terminal His10-tagged CFTR G551D mutant in liposomes of egg phosphatidylcholine assessed as increase in iodine influx at 10 uM after 5 mins by patch clamp electrophysiology assay in presence of protein kinase A and valinomycin relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
19. | ALA1954587 | B | Corrector activity at human CFTR delta F508 mutant expressed in rat FRT cells coexpressing fluorescent protein YFP-H148Q/1152L by fluorescence assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
20. | ALA902267 | B | Inhibition of CFRT-mediated chloride transport in human bronchial epithelial cells by voltage clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature |