| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA644936 | B | Inhibitory activity against Acid sphingomyelinase from bovine brain microsome | Bos taurus | 1 | ALA1136263 | assay format | Scientific Literature | |
| 2. | ALA644937 | B | Inhibitory activity against Acid sphingomyelinase | 6 | ALA1144976 | single protein format | Scientific Literature | ||
| 3. | ALA699145 | B | Compound was evaluated as a substrate for human placental acidic sphingomyelinase utilizing the usual substrate C14-labeled sphingomyelin. | 4 | ALA1152073 | assay format | Scientific Literature | ||
| 4. | ALA943086 | B | Inhibition of ASM in human H4 cells assessed as residual activity at 10 uM | Homo sapiens | 73 | ALA1140694 | cell-based format | Scientific Literature | |
| 5. | ALA1794495 | F | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | 13,233 | ALA1201862 | assay format | PubChem BioAssays | ||
| 6. | ALA2026242 | B | Inhibition of aSMase expressed in human A549 cells using 6-hexadecanoylamino-4-methylumbelliferylphosphorylcholine as substrate at 20 uM after 2 hrs by spectrophotometry | Homo sapiens | 1 | ALA2021903 | cell-based format | Scientific Literature | |
| 7. | ALA2026243 | B | Inhibition of aSMase expressed in human A549 cells using 6-hexadecanoylamino-4-methylumbelliferylphosphorylcholine as substrate at 40 uM after 2 hrs by spectrophotometry | Homo sapiens | 1 | ALA2021903 | cell-based format | Scientific Literature | |
| 8. | ALA2026165 | B | Inhibition of aSMase expressed in human A549 cells using 6-hexadecanoylamino-4-methylumbelliferylphosphorylcholine as substrate at 10 uM after 2 hrs by spectrophotometry | Homo sapiens | 1 | ALA2021903 | cell-based format | Scientific Literature | |
| 9. | ALA2026166 | B | Inhibition of human aSMase using 6-hexadecanoylamino-4-methylumbelliferylphosphorylcholine as substrate at 100 uM preincubated for 30 mins prior substrate addition measured after 2 hrs by spectrophotometry | Homo sapiens | 3 | ALA2021903 | single protein format | Scientific Literature | |
| 10. | ALA2114831 | F | PubChem BioAssay. qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate. (Class of assay: confirmatory) | Homo sapiens | ⋯ | ALA1201862 | assay format | PubChem BioAssays | |
| 11. | ALA3382959 | B | Inhibition of lysosomal ASMase activity in human MCF7 cells assessed as [methyl-14C]choline release at 10 uM after 1 hr | Homo sapiens | 1 | ALA3351606 | cell-based format | Scientific Literature | |
| 12. | ALA3382960 | B | Inhibition of lysosomal ASMase activity in human MCF7 cells assessed as [methyl-14C]choline release at 1 uM after 1 hr | Homo sapiens | 1 | ALA3351606 | cell-based format | Scientific Literature | |
| 13. | ALA3880111 | B | Inhibition of recombinant human acid sphingomyelinase expressed in HEKfreestyle293 cells using bodipy-C12 sphingomyelin as substrate and nanomolar to low micromolar concentration of compound after 1 hr by fluorescence assay | Homo sapiens | 63 | ALA3879900 | cell-based format | Patent Bioactivity Data | |
| 14. | ALA4152411 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method | Homo sapiens | 50 | ALA4152184 | single protein format | Scientific Literature | |
| 15. | ALA4152413 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates assessed as enzyme residual activity at 25 uM using 3H-sphingomyelin as substrate preincubated for 30 mins followed by mmLDL stimulation measured after 2 hrs by HPLC method | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature | |
| 16. | ALA4152414 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates up to 2 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature | |
| 17. | ALA4152415 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates at 2 to 50 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature | |
| 18. | ALA4152416 | B | Inhibition of TNFalpha-stimulated acid sphingomyelinase in human PBMC lysates at 2 to 50 uM preincubated for 30 mins followed by TNFalpha stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature | |
| 19. | ALA4152417 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates preincubated with compound followed by mmLDL stimulation by YO-PRO-1/Hoechst 33342 staining based assay | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature | |
| 20. | ALA4152418 | B | Inhibition of mmLDL-stimulated acid sphingomyelinase in human PBMC lysates up to 10 uM preincubated for 30 mins followed by mmLDL stimulation measured after 4 hrs by YO-PRO-1/Hoechst 33342 staining based assay | Homo sapiens | 1 | ALA4152184 | single protein format | Scientific Literature |
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