| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3997540 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 15 mins followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3997541 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 hrs followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based fluorescence assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 3. | ALA3997542 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate measured every 2 minutes for 50 minutes by Amplex red dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA3997543 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 4 hrs followed by substrate addition measured every 2 minutes for 50 minutes by Amplex red dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA3997544 | B | Irreversible inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production at 1000 times IC50 using DAP as substrate preincubated for 2 hrs followed by compound washout and second incubation for 2 hrs before substrate addition measured every 2 mins for 40 mins by Amplex red dye based fluorescence assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA3997545 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells spiked into human whole blood assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 followed by substrate addition measured every 90 secs for 45 mins by Amplex red dye based fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA3997546 | B | Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated for 2 hrs followed by substrate addition measured every 2 minutes for 50 minutes in presence of BSA by Amplex red dye based fluorescence assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA3997557 | B | Ratio of IC50 for full length recombinant human LOXL2 expressed in CHO cells spiked into human whole blood to IC50 for full length recombinant human LOXL2 expressed in CHO cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 9. | ALA3997559 | B | Irreversible inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production at 1000 times IC50 using DAP as substrate preincubated for 2 hrs followed by compound washout and second incubation up to 24 hrs before substrate addition measured every 2 mins for 40 mins by Amplex red dye based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4052329 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 11. | ALA4052330 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 15 mins followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4052331 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated with enzyme followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4052332 | B | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 14. | ALA4052334 | B | Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 15. | ALA4052343 | B | Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 2 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 16. | ALA4052344 | B | Irreversible inhibition of human LOXL2 assessed as catalytic activity preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | single protein format | Scientific Literature | ||
| 17. | ALA4052349 | B | Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 24 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 18. | ALA4235820 | B | Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 19. | ALA4235824 | B | Inhibition of recombinant LOXL2 (unknown origin) expressed in NS0 cells at 10 uM using diaminopentane as substrate preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorimetric method relative to control | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 20. | ALA4305230 | B | Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 20 mins followed by substrate addition by ROS-Glo assay | Homo sapiens | 3 | cell-based format | Scientific Literature |
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