| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3813383 | F | Antagonist activity at N-terminal HA-tagged TDAG8 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of pH dependent cAMP response element-driven transcriptional activity at >1 uM at pH 7.2 incubated for 6 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA3813385 | F | Antagonist activity at N-terminal HA-tagged TDAG8 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of pH dependent cAMP response element-driven transcriptional activity at pH 7.2 incubated for 6 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4044423 | F | Antagonist activity at human TDAG8 expressed in human HeLa cells assessed as inhibition of IBMX-induced cAMP accumulation preincubated for 10 mins followed by IBMX addition measured after 15 mins by using batch column chromatography | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4178750 | F | Inhibition of TDAG8 (unknown origin) expressed in human HeLa cells assessed as reduction in cAMP accumulation | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4407314 | F | Positive allosteric modulation of human GPR65 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production at higher concentration in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA4407339 | F | Positive allosteric modulation of human GPR65 expressed in HEK293T cells co-expressing Gs assessed as stimulation of proton-mediated cAMP production in HBSS buffer containing pH 6.8 to 8.2 HEPES/pH 8.3 to 8.6 TAPS measured after 20 to 30 mins in presence of PDE inhibitor Ro 20-1724 by luciferase-glo reporter gene assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4883464 | B | PRESTO-Tango GPCRome screening (GPR65) | 1 | single protein format | Donated Chemical Probes - SGC Frankfurt |
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