# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA657984 | B | In vitro inhibition of porcine carboxylesterase. | 21 | ALA1135680 | single protein format | Scientific Literature | ||
2. | ALA917586 | B | Inhibition of porcine liver carboxylesterase using [14C]GS-7340 substrate | Sus scrofa | 3 | ALA1142204 | assay format | Scientific Literature | |
3. | ALA931028 | B | Inhibition of pig liver carboxylesterase after 5 mins | Sus scrofa | 15 | ALA1141638 | assay format | Scientific Literature | |
4. | ALA931029 | B | Inhibition of pig liver carboxylesterase after 15 mins | Sus scrofa | 15 | ALA1141638 | assay format | Scientific Literature | |
5. | ALA930044 | B | Inhibition of pig liver carboxylesterase after 5 mins | Sus scrofa | 1 | ALA1141638 | assay format | Scientific Literature | |
6. | ALA930045 | B | Inhibition of pig liver carboxylesterase after 15 mins | Sus scrofa | 1 | ALA1141638 | assay format | Scientific Literature | |
7. | ALA1056160 | B | Inhibition of pig liver carboxylesterase by Lineweaver-Burke analysis | Sus scrofa | 3 | ALA1155211 | assay format | Scientific Literature | |
8. | ALA1925665 | B | Inhibition of pig liver carboxylesterase using p-nitrophenyl acetate as substrate by spectrophotometric analysis | Sus scrofa | 10 | ALA1921786 | assay format | Scientific Literature | |
9. | ALA3082113 | B | Inhibition of Sus scrofa (pig) carboxylesterase isolated from liver in using p-nitrophenyl acetate as substrate incubated for 5 min prior to substrate addition measured for 2 min by spectrophotometric analysis | Sus scrofa | 10 | ALA3046597 | assay format | Scientific Literature | |
10. | ALA3384126 | A | Prodrug conversion assessed as pseudo-first-order rate constant for porcine liver esterase-mediated prodrug conversion measured every 4 minutes for 100 mins by UV-visible absorption spectroscopy | Sus scrofa | 5 | ALA3351375 | tissue-based format | Scientific Literature | |
11. | ALA3384127 | A | Prodrug conversion assessed as half life for porcine liver esterase-mediated prodrug conversion measured every 4 minutes for 100 mins by UV-visible absorption spectroscopy | Sus scrofa | 5 | ALA3351375 | tissue-based format | Scientific Literature | |
12. | ALA3625443 | A | Stability assessed as porcine liver esterase-mediated drug degradation by measuring compound remaining level in pH 7.4 potassium phosphate buffer at 10 uM incubated for 0.25 hrs by LC/MS/MS | Sus scrofa | 2 | ALA3621120 | tissue-based format | Scientific Literature | |
13. | ALA3625444 | A | Stability assessed as porcine liver esterase-mediated drug degradation by measuring compound remaining level in pH 7.4 potassium phosphate buffer at 10 uM incubated for 0.5 hrs by LC/MS/MS | Sus scrofa | 2 | ALA3621120 | tissue-based format | Scientific Literature | |
14. | ALA3625445 | A | Stability assessed as porcine liver esterase-mediated drug degradation by measuring compound remaining level in pH 7.4 potassium phosphate buffer at 10 uM incubated for 1 hr by LC/MS/MS | Sus scrofa | 2 | ALA3621120 | tissue-based format | Scientific Literature | |
15. | ALA3757703 | B | Inhibition of porcine liver carboxylesterase using 4-nitrophenol acetate as substrate by spectrophotometric analysis | Sus scrofa | 31 | ALA3751845 | assay format | Scientific Literature | |
16. | ALA3757708 | B | Noncompetitive inhibition of porcine liver carboxylesterase using 4-nitrophenol acetate as substrate assessed as steady state inhibition constant preincubated for 10 mins followed by substrate addition by Lineweaver-Burk double reciprocal plot analysis | Sus scrofa | 9 | ALA3751845 | assay format | Scientific Literature | |
17. | ALA3802359 | B | Inhibition of porcine liver esterase using 4-nitrophenyl butyrate substrate assessed as reduction in p-nitrophenol release measured over 5 mins | Sus scrofa | 6 | ALA3797043 | assay format | Scientific Literature | |
18. | ALA4036175 | A | Drug metabolism assessed as porcine liver carboxylic-ester hydrolase-mediated compound hydrolysis by measuring half-life by HPLC analysis | Sus scrofa | 7 | ALA4033713 | assay format | Scientific Literature | |
19. | ALA4036176 | A | Drug metabolism assessed as porcine liver carboxylic-ester hydrolase-mediated formation of plinabulin after 48 hrs by HPLC method | Sus scrofa | 2 | ALA4033713 | assay format | Scientific Literature | |
20. | ALA4036177 | A | Drug metabolism assessed as porcine liver carboxylic-ester hydrolase-mediated formation of KPU-300 after 48 hrs by HPLC method | Sus scrofa | 1 | ALA4033713 | assay format | Scientific Literature |