# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3819944 | Binding | Activation of TRAAK (unknown origin) expressed in Xenopus oocytes assessed as increase in channel currents | Homo sapiens | 1 | ALA3817738 | cell-based format | Scientific Literature | |
2. | ALA3819958 | Binding | Inhibition of of human TRAAK expressed in HEK293 cells assessed as reduction in channel currents at 10 uM | Homo sapiens | 1 | ALA3817738 | cell-based format | Scientific Literature | |
3. | ALA4359048 | Binding | Activation of recombinant human TRAAK expressed in HEK293T cells assessed as increase in K+ current amplitude by whole cell voltage clamp electrophysiological analysis | Homo sapiens | 1 | ALA4354866 | cell-based format | Scientific Literature | |
4. | ALA4359050 | Binding | Activation of recombinant human TRAAK expressed in HEK293T cells assessed as increase in K+ current amplitude at 10 uM by whole cell voltage clamp electrophysiological analysis relative to control | Homo sapiens | 1 | ALA4354866 | cell-based format | Scientific Literature | |
5. | ALA4359068 | Binding | Activation of recombinant human TRAAK D227Y mutant expressed in HEK293T cells assessed as increase in K+ current amplitude at 10 uM by whole cell voltage clamp electrophysiological analysis relative to control | Homo sapiens | 1 | ALA4354866 | cell-based format | Scientific Literature | |
6. | ALA3993346 | Binding | Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 20 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | ALA3992520 | cell-based format | Scientific Literature | |
7. | ALA3993347 | Binding | Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 10 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | ALA3992520 | cell-based format | Scientific Literature | |
8. | ALA3993348 | Binding | Agonist activity at TRAAK (unknown origin) expressed in HEK293 cells assessed as increase in K+ current at 100 uM measured at +60 mV by whole-cell patch clamp method relative to control | Homo sapiens | 1 | ALA3992520 | cell-based format | Scientific Literature | |
9. | ALA4419085 | Binding | Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
10. | ALA4419088 | Binding | Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at 100 uM at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4418913 | cell-based format | Patent Bioactivity Data | |
11. | ALA4419096 | Binding | Binding affinity to K2P4.1 (unknown origin) assessed as induction of protein cross linking and labelling at 1 to 200 uM following 254 nm UV light irradiation for 30 secs by SDS-PAGE analysis | Homo sapiens | 1 | ALA4418913 | single protein format | Patent Bioactivity Data | |
12. | ALA4421813 | Binding | Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
13. | ALA4421815 | Binding | Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential at 100 uM by two-electrode voltage clamp assay relative to control | Homo sapiens | 1 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
14. | ALA4421825 | Binding | Binding affinity to purified TRAAK (unknown origin) at 1 to 200 uM following exposure to 254 nm UV light for 30 secs by SDS-PAGE and streptavidin-HRP detection based assay | Homo sapiens | 1 | ALA4421719 | single protein format | Patent Bioactivity Data | |
15. | ALA4421854 | Binding | Activation of K2P4.1 (unknown origin) expressed in Xenopus oocytes assessed as effect on channel currents at -80 mV holding potential by two-electrode voltage clamp assay relative to control | Homo sapiens | 1 | ALA4421719 | cell-based format | Patent Bioactivity Data | |
16. | ALA4667313 | Binding | Activation of K2P4.1 (unknown origin) at 30 uM by manual patch clamp method relative to control | Homo sapiens | 1 | ALA4665650 | assay format | Scientific Literature | |
17. | ALA4670290 | Binding | Inhibition of human TRAAK at intermediate transition state expressed in CHO cells by whole-cell patch-clamp electrophysiological method | Homo sapiens | 1 | ALA4665784 | cell-based format | Scientific Literature | |
18. | ALA5100507 | Binding | Inhibition of human TRAAK expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay | Homo sapiens | 1 | ALA5096243 | cell-based format | Scientific Literature |