# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3720980 | B | Inhibition of N-terminal Flag-tagged mouse TRPM7 expressed in HEK293T cells assessed as reduction in whole cell currents by whole-cell patch clamp assay | Mus musculus | 14 | cell-based format | Patent Bioactivity Data | ||
2. | ALA3720983 | B | Inhibition of N-terminal Flag-tagged mouse TRPM7 expressed in HEK293T cells assessed as reduction in whole cell currents under oxygen-glucose deprivation by whole-cell patch clamp assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
3. | ALA3734567 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as inhibition of channel-mediated cell death in presence of Mg2+ incubated for 24 to 48 hrs by propidium iodide uptake assay | Mus musculus | 359 | cell-based format | Patent Bioactivity Data | ||
4. | ALA3734569 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as reduction in channel currents at 0.3 to 30 uM by whole cell patch clamp assay | Mus musculus | 6 | cell-based format | Patent Bioactivity Data | ||
5. | ALA3734581 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as reduction in channel currents at 2 mM using compound applied intracellularly by whole cell patch clamp assay | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA3734582 | B | Inhibition of Tet-induced Flag-tagged mouse TRPM7 expressed in HEK293 cells assessed as reduction in channel currents at 2 mM using compound applied extracellularly by whole cell patch clamp assay | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
7. | ALA3734583 | B | Inhibition of TRPM7 in mouse primary neuronal cells exposed to oxygen glucose deprivation condition for 1 to 3 hrs assessed as reduction in TRPM7-mediated anoxic cell death dosed before oxygen glucose deprivation condition by propidium iodide uptake assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
8. | ALA3734584 | B | Inhibition of TRPM7 in mouse primary neuronal cells exposed to oxygen glucose deprivation condition for 1 to 3 hrs assessed as reduction in TRPM7-mediated anoxic cell death dosed after oxygen glucose deprivation condition by propidium iodide uptake assay | Mus musculus | 6 | organism-based format | Patent Bioactivity Data | ||
9. | ALA3734622 | B | Inhibition of TRPM7 in mouse mouse primary cortical neurons exposed to 2 hrs oxygen glucose deprivation condition assessed as reduction in TRPM7-mediated anoxic cell death measured after 20 hrs by propidium iodide uptake assay | Mus musculus | 6 | cell-based format | Patent Bioactivity Data | ||
10. | ALA3734623 | B | Inhibition of TRPM7 in mouse mouse primary cortical neurons exposed to 1 hrs oxygen glucose deprivation condition assessed as reduction in TRPM7-mediated anoxic cell death at 1.25 to 10 uM measured after 20 hrs by propidium iodide uptake assay | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
11. | ALA3734624 | B | Inhibition of TRPM7 in mouse mouse primary cortical neurons exposed to 2 hrs oxygen glucose deprivation condition assessed as reduction in TRPM7-mediated anoxic cell death at 0.625 to 5 uM pre-incubated for 24 hrs before OGD measured after 20 hrs by propidium iodide uptake assay | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA3734625 | B | Inhibition of TRPM7 in mouse AML12 cells assessed as protection against oxygen glucose deprivation-induced cell death at 0.5 to 5 uM | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4134889 | B | Inhibition of mouse FLAG-tagged TRPM7 expressed in HEK293 cells assessed as reduction in BAPTA-induced intracellular calcium flux at 0.1 to 2 uM by whole cell patch clamp electrophysiology method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
14. | ALA4134890 | B | Inhibition of mouse FLAG-tagged TRPM7 expressed in HEK293 cells assessed as reduction in BAPTA-induced intracellular calcium flux after 15 to 60 mins by whole cell patch clamp electrophysiology method | Mus musculus | 1 | cell-based format | Scientific Literature | ||
15. | ALA4420654 | B | Inhibition of TRPM7 in mouse NMuMG cells assessed as suppression of TGFbeta1-induced EMT by measuring alpha-SMA expression at 25 to 50 uM incubated for 24 to 72 hrs by Western blot analysis | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
16. | ALA4420655 | B | Inhibition of TRPM7 in mouse NMuMG cells assessed as suppression of TGFbeta1-induced calpain activity by measuring Filamin-A levels at 25 to 50 uM incubated for 24 to 72 hrs by Western blot analysis | Mus musculus | 2 | cell-based format | Patent Bioactivity Data |