| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3768327 | B | Binding affinity to LRP6 in human SH-SY5Y cells assessed as DKK1/LRP6 interaction-mediated increase in beta-catenin level at 10 uM incubated for 1 hr using compound pre-treated DKK1 conditioned media by Western blot analysis | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 2. | ALA3768328 | B | Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned media after 2 hrs by fluorescence microscopic analysis | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 3. | ALA3768330 | B | Binding affinity to LRP6 in human SH-SY5Y cells assessed as inhibition of DKK1/LRP6 interaction-mediated tau phosphorylation at serine 396 at 10 uM incubated for 1 hr using compound pre-treated DKK1 conditioned media by Western blot analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA3768331 | B | Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned medium | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4221466 | B | Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring luciferase activity at 3 uM after 24 hrs by dual-luciferase reporter gene assay (Rvb = 100 +/- 3.1%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 6. | ALA4221468 | B | Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring luciferase activity at 0.3 uM after 24 hrs by dual-luciferase reporter gene assay (Rvb = 100 +/- 2.6%) | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 7. | ALA4221469 | B | Inhibition of sclerostin binding to LRP6 (unknown origin) expressed in rat MC3T3-E1 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in sclerostin-induced inhibition of Wnt3a activation by measuring increase in luciferase activity after 24 hrs by dual-luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature |
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