Prodrug conversion assessed as porcine leucine aminopeptidase-mediated (Z)-2-(20,30-Diamino-40-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene formation after 25 hrs using 0.12 units of enzyme by HPLC analysis
Prodrug conversion assessed as porcine leucine aminopeptidase-mediated (Z)-2-(20,30-Diamino-40-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene formation after 24 hrs using 1.5 units of enzyme by HPLC analysis
Prodrug conversion assessed as porcine leucine aminopeptidase-mediated (Z)-2-(20,30-Diamino-40-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene formation after 24 hrs using 3.7 units of enzyme by HPLC analysis
Drug level assessed as porcine leucine aminopeptidase-mediated compound formation treated with (Z)-N,N''-(3-Methoxy-6-(3,4,5-trimethoxystyryl)-1,2-phenylene)bis(2-aminoacetamide) after 25 hrs using 1.5 units of enzyme by HPLC analysis
Drug level assessed as porcine leucine aminopeptidase-mediated compound formation treated with (Z)-N,N''-(3-Methoxy-6-(3,4,5-trimethoxystyryl)-1,2-phenylene)bis(2-aminoacetamide) after 25 hrs using 0.12 units of enzyme by HPLC analysis
Drug level assessed as porcine leucine aminopeptidase-mediated compound formation treated with (Z)-N,N''-(3-Methoxy-6-(3,4,5-trimethoxystyryl)-1,2-phenylene)bis(2-aminoacetamide) after 25 hrs using 3.7 units of enzyme by HPLC analysis