| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA5256274 | B | Displacement of fluorescent tracer from NanoLuc-tagged CRBN (unknown origin) by NanoBRET assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 2. | ALA3768094 | B | Binding affinity to human CRBN (delta 1 to 315) by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA3768098 | B | Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 4. | ALA3768102 | B | Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysis | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 5. | ALA4183659 | B | Displacement of Atto565-Lenalidomide from CRBN fused with DDB1deltaB (unknown origin) by fluorescence polarization assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA4219431 | B | Displacement of cy5-conjugated 2-((1E,3E,5Z)-5-(1-(6-((4-(2-((2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)acetamido)butyl)amino)-6-oxohexyl)-3,3-dimethylindolin-2-ylidene)penta-1,3-dien-1-yl)-1,3,3-trimethyl-3H-indol-1-ium from DDB1-fused human full length 6xHis-tagged CRBN expressed in Sf9 insect cells after 10 mins by TR-FRET assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4323220 | B | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 days | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4323221 | B | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured after 4 days | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4323222 | B | Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 days | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4323223 | B | Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 days | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4323224 | B | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4323225 | B | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in presence of 30 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4323226 | B | Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in presence of 100 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4323227 | B | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4323228 | B | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition measured after 4 days in presence of 30 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4323229 | B | Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition measured after 4 days in presence of 100 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4323230 | B | Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM of lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4323231 | B | Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 30 uM of lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4323232 | B | Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 100 uM of lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4323233 | B | Binding affinity to cereblon in human MDA-MB-468 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM lenalidomide | Homo sapiens | 1 | cell-based format | Scientific Literature |
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