Inhibition of CYP17A1 in cynomolgus monkey adrenal microsomes using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity assay in presence of NADPH
Inhibition of CYP17A1 in cynomolgus monkey using [3H]-pregnenolone as substrate incubated for 45 mins by scintillation proximity assay in presence of NADPH
Selectivity ratio of cynomolgus monkey CYP17A1 hydroxylase activity using pregnenolone substrate to cynomolgus monkey CYP17A1 lyase activity using [3H]-hydroxypregnenolone substrate
Invivo inhibition of inhibition of CYP17A1 in cynomolgus monkey assessed as reduction in testosterone level in plasma at 1 mg/kg, po by radiometric immunoassay
Invivo inhibition of CYP17A1 in one day castrated cynomolgus monkey assessed as reduction in testosterone level in plasma at 1.5 mg/kg, po bid for 24 hrs by radiometric immunoassay
Invivo inhibition of CYP17A1 in one day castrated cynomolgus monkey assessed as reduction in testosterone level in plasma at 42 mg/kg, po bid for 24 hrs by radiometric immunoassay
Selectivity ratio of IC50 for inhibition of cynomolgus monkey CYP17A1 hydroxylase activity to IC50 for inhibition of cynomolgus monkey CYP17A1 lyase activity
Invivo inhibition of CYP17A1 in cynomolgus monkey assessed as decrease in testosterone level in blood at 1 mg/kg, po measured upto 24 hrs relative to control