| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3784290 | B | Inhibition of NLRP3 in mouse BMDM cells preincubated for 30 mins followed by ATP addition by ELISA analysis | Mus musculus | 1 | ALA3779837 | cell-based format | Scientific Literature | |
| 2. | ALA3784390 | B | Inhibition of NLRP3 in LPS stimulated mouse BMDM cells after 15 mins followed by addition of ATP by ELISA analysis | Mus musculus | 1 | ALA3779837 | cell-based format | Scientific Literature | |
| 3. | ALA3784393 | B | Inhibition of NLRP3 in mouse J774 macrophages assessed as reduction in Bacillus anthracis lethal toxin induced cell death | Mus musculus | 1 | ALA3779837 | single protein format | Scientific Literature | |
| 4. | ALA3864050 | B | Inhibition of NLRP3 inflammasome activation in LPS-stimulated mouse BMDM assessed as reduction in NLRP3 inflammasome-induced IL-1beta production preincubated for 30 mins followed by NLRP3 stimulation with ATP by ELISA | Mus musculus | 1 | ALA3862040 | single protein format | Scientific Literature | |
| 5. | ALA4015429 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced IL-1beta production at 10 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 6. | ALA4015430 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced IL-1beta production at 10 uM preincubated for 1 hr followed by stimulation with nigericin measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 7. | ALA4015431 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced IL-1beta production at 10 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 8. | ALA4015432 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced IL-1beta production at 10 to 100 uM preincubated for 1 hr followed by stimulation with nigericin measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 9. | ALA4015433 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced IL-1beta production at 1 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 10. | ALA4015434 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced IL-1beta production at 1 to 100 uM preincubated for 1 hr followed by stimulation with nigericin measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 11. | ALA4015435 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced caspase-1 activation at 10 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 12. | ALA4015436 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced caspase-1 activation at 10 to 100 uM preincubated for 1 hr followed by stimulation with nigericin measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 13. | ALA4015439 | B | Inhibition of NLRP3 in C57BL/6 mouse bone marrow derived macrophages assessed as reduction in LPS-induced IL-1beta gene expression at 10 to 100 uM preincubated for 30 mins followed by LPS stimulation measured after 4 hrs by qRT-PCR analysis | Mus musculus | 1 | ALA4014309 | assay format | Scientific Literature | |
| 14. | ALA4015441 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced pyroptosis at 100 to 250 nM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by LDH release assay | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 15. | ALA4015442 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced pyroptosis at 100 to 250 nM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by LDH release assay | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 16. | ALA4015443 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced IL-1beta production at 10 to 250 nM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 17. | ALA4015444 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced IL-1beta production at 10 to 250 nM preincubated for 1 hr followed by stimulation with nigericin measured after 30 mins by ELISA | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature | |
| 18. | ALA4015487 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced pyroptosis at 10 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by LDH release assay | Mus musculus | 2 | ALA4014309 | single protein format | Scientific Literature | |
| 19. | ALA4015488 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in nigericin-induced pyroptosis at 10 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by LDH release assay | Mus musculus | 2 | ALA4014309 | single protein format | Scientific Literature | |
| 20. | ALA4015489 | B | Inhibition of NLRP3 inflammasome in LPS-primed C57BL/6 mouse bone marrow derived macrophages assessed as reduction in ATP-induced pyroptosis at 1 to 100 uM preincubated for 1 hr followed by stimulation with ATP measured after 30 mins by LDH release assay | Mus musculus | 1 | ALA4014309 | single protein format | Scientific Literature |
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