#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA3789118	B	Binding affinity to mouse RIP1 (1 to 378 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay	Mus musculus	3	ALA3785028	single protein format	Scientific Literature
2.	ALA3789353	B	Inhibition of mouse RIP1 in mouse L929 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis by Cell titer-Glo luminescence assay	Mus musculus	3	ALA3785028	cell-based format	Scientific Literature
3.	ALA3789355	B	Inhibition of mouse WT RIP1 transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISA	Mus musculus	1	ALA3785028	cell-based format	Scientific Literature
4.	ALA3789358	B	Inhibition of mouse RIP1 V159L mutant transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISA	Mus musculus	1	ALA3785028	cell-based format	Scientific Literature
5.	ALA3993120	B	Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 6 hrs by Cell Titer-Glo luminescent cell viability assay	Mus musculus	1	ALA3992509	cell-based format	Scientific Literature
6.	ALA3993121	B	Potency index, ratio of GSK481 EC50 to compound EC50 for RIP1 in mouse L929 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis	Mus musculus	1	ALA3992509	cell-based format	Scientific Literature
7.	ALA3999310	B	Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell viability assay	Mus musculus	1	ALA3997808	cell-based format	Scientific Literature
8.	ALA3999313	B	Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2'',3'']indolizino-[8'',7'':5',6']pyrano[3',2':3,4]pyrido[1,2-a]indol-5-ium-2-sulfonate from mouse RIP1 (1 to 378 residues) expressed in baculovirus infected insect cells measured for 50 mins by fluorescence polarization assay	Mus musculus	1	ALA3997808	cell-based format	Scientific Literature
9.	ALA4024002	B	Inhibition of fluorescent-labeled 3-(3-((3-(4-amino-5-(4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)amino)-3-oxopropyl)-5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:2',1'-f]-[1,3,2]diazaborinin-4-ium-5-uide binding to mouse RIPK1 by TR-FRET assay	Mus musculus	1	ALA4020836	single protein format	Scientific Literature
10.	ALA4024007	B	Inhibition of RIPK1 in mouse L929 cells assessed as decrease in TNFalpha/zVAD-FMK-induced MLKL phosphorylation at S358 residue preincubated for 30 mins followed by TNFalpha/zVAD-FMK addition measured after 6 hrs by sandwich ELISA	Mus musculus	1	ALA4020836	cell-based format	Scientific Literature
11.	ALA4048554	B	Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay	Mus musculus	46	ALA4043285	cell-based format	Scientific Literature
12.	ALA4048556	B	Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay	Mus musculus	46	ALA4043285	cell-based format	Scientific Literature
13.	ALA4048559	B	Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis at 3 uM pretreated for 0.5 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay relative to control	Mus musculus	34	ALA4043285	cell-based format	Scientific Literature
14.	ALA4048560	B	Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis at 3 uM pretreated for 24 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay relative to control	Mus musculus	31	ALA4043285	cell-based format	Scientific Literature
15.	ALA4306773	B	Inhibition of RIP1 in mouse L929 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assay	Mus musculus	1	ALA4304764	cell-based format	Scientific Literature
16.	ALA4352160	B	Inhibition of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2''3'']indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido-[1,2-a]indol-5-ium-2-sulfonate binding to mouse RIP1 (1 to 378) expressed in baculovirus expression system preincubated for 10 mins followed by fluorescently labeled ATP-competitive ligand addition and measured after 20 mins by fluorescence polarization assay	Mus musculus	1	ALA4350963	assay format	Scientific Literature
17.	ALA4352202	B	Inhibition of RIP1 in mouse L929 cells assessed as reduction in TNF/zVAD.fmk-induced necrotic death measured after 24 hrs by cell titer-glo luminescent cell viability assay	Mus musculus	3	ALA4350963	cell-based format	Scientific Literature
18.	ALA4378716	B	Inhibition of mouse RIPK1	Mus musculus	1	ALA4376828	single protein format	Scientific Literature
19.	ALA4378740	B	Inhibition of RIPK1 in mouse RGC-5 cells incubated for 30 mins in presence of [gamma32-ATP] by SDS-PAGE based radiometric assay	Mus musculus	1	ALA4376828	cell-based format	Scientific Literature
20.	ALA4667087	B	Inhibition of mouse RIPK1 incubated for 2 hrs by fluorescence polarization assay	Mus musculus	1	ALA4665648	single protein format	Scientific Literature