# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3816047 | Binding | Agonist activity at mouse GPR174 expressed in HEK293FT cells after 1.5 hrs by alkaline phosphatase tagged-TGFalpha shedding assay | Mus musculus | 12 | ALA3813596 | cell-based format | Scientific Literature | |
2. | ALA4807191 | Functional | Inhibition of mouse GPR174 in anti-CD3/antiCD28-stimulated mouse splenocytes assessed as increase in IL-2 production at 10 uM measured after 2 days | Mus musculus | 1 | ALA4806960 | tissue-based format | Patent Bioactivity Data | |
3. | ALA5151739 | Functional | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay | Mus musculus | 21 | ALA5149997 | cell-based format | Scientific Literature | |
4. | ALA5151740 | Functional | Agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to LysoPS(18:1) | Mus musculus | 16 | ALA5149997 | cell-based format | Scientific Literature | |
5. | ALA5151741 | Functional | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay | Mus musculus | 6 | ALA5149997 | cell-based format | Scientific Literature | |
6. | ALA5151742 | Functional | Partial agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to LysoPS(18:1) | Mus musculus | 6 | ALA5149997 | cell-based format | Scientific Literature | |
7. | ALA5151743 | Functional | Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay | Mus musculus | 22 | ALA5149997 | cell-based format | Scientific Literature | |
8. | ALA5151744 | Functional | Antagonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to control | Mus musculus | 21 | ALA5149997 | cell-based format | Scientific Literature | |
9. | ALA5151745 | Functional | Inverse agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay | Mus musculus | 1 | ALA5149997 | cell-based format | Scientific Literature | |
10. | ALA5151746 | Functional | Inverse agonist activity at mouse GPR174 transfected in human HEK293FT cells co-transfected with AP-TGFalpha assessed as inhibition of LysoPalloT-NH-C3-ph-m-O-C11-induced AP-TGFalpha release incubated for 90 mins by TGFalpha shedding assay relative to control | Mus musculus | 1 | ALA5149997 | cell-based format | Scientific Literature |