# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3829630 | B | Inhibition of ATX in mouse plasma assessed as inhibition of LPA production after 2 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA3826953 | cell-free format | Scientific Literature | |
2. | ALA3829634 | B | Inhibition of recombinant mouse ATX using lysophosphatidylcholine as substrate by choline release assay | Mus musculus | 1 | ALA3826953 | single protein format | Scientific Literature | |
3. | ALA3998945 | B | Inhibition of ATX in mouse 4T1 cells assessed as potentiation of paclitaxel-induced antiproliferative activity by measuring paclitaxel LD50 at 3 uM preincubated for 24 hrs followed by paclitaxel addition measured after 48 hrs by CellTiter blue assay (Rvb = 202 nM) | Mus musculus | 2 | ALA3997796 | cell-based format | Scientific Literature | |
4. | ALA3998946 | B | Inhibition of ATX in paclitaxel-resistant mouse 4T1 cells assessed as potentiation of paclitaxel-induced antiproliferative activity by measuring reduction in cell viability at 5 uM measured after 3 days by CellTiter blue assay | Mus musculus | 2 | ALA3997796 | assay format | Scientific Literature | |
5. | ALA4049298 | B | Inhibition of mouse ATX-beta using LPC 16:0 as substrate by Amplex Red PLD assay | Mus musculus | 25 | ALA4043308 | single protein format | Scientific Literature | |
6. | ALA4049299 | B | Inhibition of mouse ATX-beta using LPC 18:0 as substrate by Amplex Red PLD assay | Mus musculus | 7 | ALA4043308 | single protein format | Scientific Literature | |
7. | ALA4049309 | B | Inhibition of recombinant mouse ATX expressed in HEK293 cells using FS3 as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins | Mus musculus | 1 | ALA4043308 | cell-based format | Scientific Literature | |
8. | ALA4049310 | B | Inhibition of recombinant mouse ATX expressed in HEK293 cells using LPC 17:0 as substrate after 30 mins by LC-MS/MS method | Mus musculus | 1 | ALA4043308 | cell-based format | Scientific Literature | |
9. | ALA4051890 | B | Inhibition of ATX in mouse plasma assessed as reduction in LPA 18:2 production after 2 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4049443 | single protein format | Scientific Literature | |
10. | ALA4052574 | B | Inhibition of mouse ATX using TG-mTMP as substrate after 2 hrs by fluorometric analysis | Mus musculus | 3 | ALA4049463 | single protein format | Scientific Literature | |
11. | ALA4404852 | B | Inhibition of mouse ATX expressed in one-cell stage zebra fish embryos assessed as rescue of cardia bifida phenotype at 10 uM incubated for 12 to 24 hrs post fertilization in presence of Ki16425 by whole mount in situ hybridization based microscopic analysis relative to control | Mus musculus | 6 | ALA4402579 | assay format | Scientific Literature | |
12. | ALA4404854 | B | Inhibition of ATX in mouse plasma after 2 hrs by LC-MS/MS analysis | Mus musculus | 51 | ALA4402579 | cell-free format | Scientific Literature | |
13. | ALA4404855 | B | Inhibition of ATX in mouse plasma assessed as reduction in LPA prodution at 10 uM after 3 hrs by LC-MS/MS analysis | Mus musculus | 30 | ALA4402579 | cell-free format | Scientific Literature | |
14. | ALA4404856 | B | Inhibition of ATX in mouse plasma assessed as reduction in LPA prodution after 3 hrs by LC-MS/MS analysis | Mus musculus | 3 | ALA4402579 | cell-free format | Scientific Literature | |
15. | ALA4613084 | B | Inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysis | Mus musculus | 1 | ALA4610127 | cell-free format | Scientific Literature | |
16. | ALA4613086 | B | Potency index, ratio of IC50 for GLPG1690 to IC50 for test compound for inhibition of autotaxin in mouse plasma assessed as reduction in LPA (18:2) production incubated for 2 hrs LC-MS-/MS analysis | Mus musculus | 1 | ALA4610127 | cell-free format | Scientific Literature |