# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA615352 | B | Tested in vitro for inhibition of chymotrypsin like activity of purified human 20S proteasome | Homo sapiens | 19 | ALA1136019 | subcellular format | Scientific Literature | |
2. | ALA615353 | B | Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain | Homo sapiens | 7 | ALA1128409 | subcellular format | Scientific Literature | |
3. | ALA834792 | F | Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined | Homo sapiens | 13 | ALA1143504 | subcellular format | Scientific Literature | |
4. | ALA837922 | F | Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined | Homo sapiens | 13 | ALA1143504 | subcellular format | Scientific Literature | |
5. | ALA874816 | F | Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined | Homo sapiens | 13 | ALA1143504 | subcellular format | Scientific Literature | |
6. | ALA909078 | B | Inhibition of human 20S proteasome | Homo sapiens | 8 | ALA1141377 | subcellular format | Scientific Literature | |
7. | ALA4199261 | B | Inhibition of 20S proteasome activity in human ANBL-6 cells | Homo sapiens | 1 | ALA4196096 | cell-based format | Scientific Literature | |
8. | ALA4357205 | B | Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay | Homo sapiens | 5 | ALA4354831 | protein complex format | Scientific Literature | |
9. | ALA4357206 | B | Inhibition of 20S proteasome in human HeLa cells at 2xIC50 using LLVY-R110 peptide as substrate measured up to 36 hrs by fluorescence based assay | Homo sapiens | 2 | ALA4354831 | cell-based format | Scientific Literature | |
10. | ALA4357207 | B | Inhibition of 20S proteasome in human BE(2)-C cells at 2xIC50 using LLVY-R110 peptide as substrate measured up to 36 hrs by fluorescence based assay | Homo sapiens | 2 | ALA4354831 | cell-based format | Scientific Literature | |
11. | ALA4357208 | B | Potency index, ratio of ixazomib IC50 to compound IC50 for inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay | Homo sapiens | 2 | ALA4354831 | protein complex format | Scientific Literature | |
12. | ALA4371818 | B | Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in human alpha-synuclein degradation at 1 uM after 1 hr by SDS-PAGE analysis | Homo sapiens | 4 | ALA4371016 | assay format | Scientific Literature | |
13. | ALA4371819 | B | Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in human alpha-synuclein degradation at 10 uM after 1 hr by SDS-PAGE analysis | Homo sapiens | 7 | ALA4371016 | assay format | Scientific Literature | |
14. | ALA4371820 | B | Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in yeast enolase degradation at 1 uM after 1 hr by SDS-PAGE analysis | Homo sapiens | 5 | ALA4371016 | assay format | Scientific Literature | |
15. | ALA4371821 | B | Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in yeast enolase degradation at 10 uM after 1 hr by SDS-PAGE analysis | Homo sapiens | 5 | ALA4371016 | assay format | Scientific Literature | |
16. | ALA4371822 | B | Positive allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as increase in yeast enolase degradation at 1 uM after 1 hr by SDS-PAGE analysis relative to control | Homo sapiens | 2 | ALA4371016 | assay format | Scientific Literature | |
17. | ALA4371826 | B | Effect on alpha-face conformations of latent human erythrocytes 20S proteasome assessed as open state conformation at 1 uM by atomic force microscopic method (Rvb = 7%) | Homo sapiens | 2 | ALA4371016 | assay format | Scientific Literature | |
18. | ALA4371827 | B | Effect on alpha-face conformations of latent human erythrocytes 20S proteasome assessed as intermediate state conformation at 1 uM by atomic force microscopic method (Rvb = 22%) | Homo sapiens | 1 | ALA4371016 | assay format | Scientific Literature | |
19. | ALA4371828 | B | Effect on alpha-face conformations of latent human erythrocytes 20S proteasome assessed as open state conformation at 10 uM by atomic force microscopic method (Rvb = 7%) | Homo sapiens | 1 | ALA4371016 | assay format | Scientific Literature | |
20. | ALA4371829 | B | Effect on alpha-face conformations of latent human erythrocytes 20S proteasome assessed as intermediate state conformation at 10 uM by atomic force microscopic method (Rvb = 22%) | Homo sapiens | 1 | ALA4371016 | assay format | Scientific Literature |