# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4411721 | B | Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha after 6 hrs by luciferase reporter gene assay | Homo sapiens | 23 | ALA4411266 | cell-based format | Scientific Literature | |
2. | ALA4411722 | B | Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha after 6 hrs by luciferase reporter gene assay relative to deferoxamine | Homo sapiens | 14 | ALA4411266 | cell-based format | Scientific Literature | |
3. | ALA4411723 | B | Inhibition of PHD in HEK293T cells assessed as increase in HIF1alpha expression at 1 to 10 uM after 3 hrs by Western blot analysis | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
4. | ALA4411727 | B | Inhibition of PHD in HEK293T cells assessed as increase in HIF1alpha expression at 10 uM after 15 to 180 mins by Western blot analysis | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
5. | ALA4411728 | B | Inhibition of PHD in HEK293T cells assessed as increase in HIF1alpha expression at 10 uM under hypoxic condition by Western blot analysis | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
6. | ALA4411731 | B | Inhibition of PHD in HEK293T cells assessed as increase in HIF1alpha expression at 10 uM under normoxic condition by Western blot analysis | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
7. | ALA4411732 | B | Inhibition of PHD in HEK293T cells assessed as increase in HIF1alpha expression at 1 to 10 uM after 6 hrs in presence of proteasome inhibitor MG132 | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
8. | ALA4411733 | B | Inhibition of PHD in HEK293T cells assessed as reduction in HIF1alpha hydroxylation at 1 to 10 uM after 6 hrs in presence of proteasome inhibitor MG132 | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
9. | ALA4411734 | B | Reversible inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha at 5 to 25 uM pretreated for 1 hr followed by compound washout and measured after 6 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature | |
10. | ALA4411735 | B | Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha at 1 to 25 uM after 6 hrs in presence of 50 uM betulinic acid by luciferase reporter gene assay | Homo sapiens | 1 | ALA4411266 | cell-based format | Scientific Literature |