# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3734578 | B | Inhibition of NMDA receptor in mouse cortical neurons assessed as effect on NMDA currents | Mus musculus | 1 | ALA3727350 | protein complex format | Patent Bioactivity Data | |
2. | ALA4835967 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current by measuring peak current amplitude at 30 uM measured after 15 to 30 mins by patch-clamp method (Rvb = 54.6 +/- 4.6 pA) | Mus musculus | 2 | ALA4834434 | tissue-based format | Scientific Literature | |
3. | ALA4835968 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone at 30 uM measured after 15 to 30 mins by patch-clamp method | Mus musculus | 61 | ALA4834434 | tissue-based format | Scientific Literature | |
4. | ALA4835969 | B | Positive allosteric modulation of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current at 10 uM in absence of exogenous glycine/D-serine by whole-cell patch clamp method | Mus musculus | 1 | ALA4834434 | tissue-based format | Scientific Literature | |
5. | ALA4835970 | B | Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current at 10 uM in presence of 30 uM exogenous glycine by whole-cell patch clamp method | Mus musculus | 1 | ALA4834434 | tissue-based format | Scientific Literature | |
6. | ALA4835973 | B | Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced current in presence of 30 uM exogenous glycine by whole-cell patch clamp method (Rvb = 23.9 +/- 1.3 uM) | Mus musculus | 1 | ALA4834434 | tissue-based format | Scientific Literature | |
7. | ALA4835974 | B | Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of NMDA-induced maximum current by whole-cell patch clamp method | Mus musculus | 1 | ALA4834434 | tissue-based format | Scientific Literature | |
8. | ALA4835975 | B | Positive allosteric modulation of of ICR mouse primary cortical neuron NMDA receptor assessed as potentiation of glycine-induced current in presence of 100 uM NMDA by whole-cell patch clamp method | Mus musculus | 1 | ALA4834434 | tissue-based format | Scientific Literature | |
9. | ALA4835982 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current in presence of saturating glutamate by patch-clamp method | Mus musculus | 6 | ALA4834434 | tissue-based format | Scientific Literature | |
10. | ALA4835983 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone in presence of saturating glutamate by patch-clamp method | Mus musculus | 6 | ALA4834434 | tissue-based format | Scientific Literature | |
11. | ALA5232430 | B | Blocking of NMDA receptor in mouse fibroblast assessed as inhibition of NMDA-induced excitotoxicity by LDH release assay | Mus musculus | 1 | ALA5230151 | cell-based format | Scientific Literature |