# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3720853 | Binding | Activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate dose response curve at 1 mM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
2. | ALA3720854 | Binding | Activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate/IMP dose response curve at 5 mM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
3. | ALA3720882 | Binding | Activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate dose response curve at 5 mM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
4. | ALA3720883 | Functional | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium response by fluo-4-AM dye based FLIPR assay | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
5. | ALA3720884 | Binding | Activation of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate dose response curve at 5 uM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
6. | ALA3720885 | Binding | Activation of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate/IMP dose response curve at 5 uM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
7. | ALA3720886 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as reduction in 8 mM L-glutamate-induced response | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
8. | ALA3720887 | Binding | Activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as induction of left-ward shift of glutamate/IMP dose response curve at 1 mM relative to untreated control | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
9. | ALA3720888 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as reduction in 80 mM L-glutamate-induced response | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
10. | ALA3720889 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as reduction in L-glutamate/IMP-induced response in presence of 0.8 mM L-glutamate | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
11. | ALA3720890 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as reduction in L-glutamate/IMP-induced response in presence of 80 mM L-glutamate | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
12. | ALA3720891 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as EC50 for L-glutamate-induced response at 25 uM (Rvb = 9.9 +/-1.5 mM) | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
13. | ALA3720892 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as EC50 for L-glutamate-induced response at 50 uM (Rvb = 9.9 +/-1.5 mM) | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
14. | ALA3720893 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as EC50 for L-glutamate/IMP-induced response at 100 uM (Rvb = 0.53 +/-0.04 mM) | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
15. | ALA3720894 | Binding | Inhibition of human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as EC50 for L-glutamate/IMP-induced response at 200 uM (Rvb = 0.53 +/-0.04 mM) | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
16. | ALA3720907 | Functional | Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay | Homo sapiens | 140 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
17. | ALA3720908 | Functional | Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as enhancement of MSG-induced calcium mobilization by measuring ratio of MSG EC50 in presence and absence of 1 uM compound by fluo-4-AM dye based FLIPR assay | Homo sapiens | 31 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
18. | ALA3720909 | Functional | Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as enhancement of MSG-induced calcium mobilization by measuring ratio of MSG EC50 in presence and absence of 0.01 uM compound by fluo-4-AM dye based FLIPR assay | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
19. | ALA3720937 | Functional | Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as enhancement of MSG-induced calcium mobilization by measuring ratio of MSG EC50 in presence and absence of 0.03 uM compound by fluo-4-AM dye based FLIPR assay | Homo sapiens | 1 | ALA3714709 | cell-based format | Patent Bioactivity Data | |
20. | ALA3720938 | Functional | Agonist activity at human T1R1/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as enhancement of MSG-induced calcium mobilization by measuring ratio of MSG EC50 in presence and absence of 0.3 uM compound by fluo-4-AM dye based FLIPR assay | Homo sapiens | 10 | ALA3714709 | cell-based format | Patent Bioactivity Data |
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