# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA1071802 | F | Activity at human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha-16-gust44 assessed as F340/F380 ratio at 1.25 mM in presence of T1R2/T1R3 antagonist lactisole | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
2. | ALA1072438 | B | Activity at human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha-16-gust44 assessed as F340/F380 ratio at 1.25 mM | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA3720852 | F | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium response by fluo-4-AM dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
4. | ALA3720895 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 50 mM sucrose-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
5. | ALA3720896 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 120 mM sucrose-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
6. | ALA3720897 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 0.1 mM saccharin-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
7. | ALA3720898 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 2 mM saccharin-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
8. | ALA3720899 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 1 mM D-tryptophan saccharin-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
9. | ALA3720900 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 15 mM D-tryptophan saccharin-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
10. | ALA3720901 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for sucrose-induced response at 10 uM (Rvb = 19.4 +/- 0.9 mM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
11. | ALA3720902 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for sucrose-induced response at 20 uM (Rvb = 19.4 +/- 0.9 mM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA3720903 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for D-Trp-induced response at 10 uM (Rvb = 0.37 +/- 0.02 mM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA3720904 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for D-Trp-induced response at 20 uM (Rvb = 0.37 +/- 0.02 mM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
14. | ALA3720905 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for saccharin-induced response at 10 uM (Rvb = 42 +/- 3 uM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
15. | ALA3720906 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as EC50 for saccharin-induced response at 20 uM (Rvb = 42 +/- 3 uM) | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
16. | ALA3720941 | F | Agonist activity at human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15 assessed as calcium mobilization by fluo-4-AM dye based FLIPR assay | Homo sapiens | 112 | cell-based format | Patent Bioactivity Data | ||
17. | ALA3720943 | B | Inhibition of human T1R2/T1R3 expressed in HEK293T cells co-expressing Galpha15/i1 assessed as reduction in 150 mM sucrose-induced response | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
18. | ALA3720965 | B | Activation of human T1R2/T1R3 | Homo sapiens | 1 | protein complex format | Patent Bioactivity Data | ||
19. | ALA4433975 | F | Agonist activity at human T1R2/T1R3 expressed in PEAKrapid cells assessed as effect on intracellular calcium influx measured for 120 secs by fluorescence based assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
20. | ALA4433976 | F | Positive allosteric modulator activity at human T1R2/T1R3 expressed in PEAKrapid cells assessed as potentiation of sucrose-induced intracellular calcium influx by measuring sucrose EC50 at 30 uM measured for 120 secs by fluorescence based assay (Rvb = 31.7 mM) | Homo sapiens | 22 | cell-based format | Scientific Literature |