# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3734545 | B | Inhibition of recombinant human STIM1/Orai1 expressed in HEK293 cells assessed as inhibition of peak basal signal after 30 mins by fluo4-AM dye-based FLIPR assay | Homo sapiens | 78 | ALA3727365 | cell-based format | Patent Bioactivity Data | |
2. | ALA3734079 | F | Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as intracellular calcium level after 30 mins by FLIPR assay | Homo sapiens | 65 | ALA3727341 | cell-based format | Patent Bioactivity Data | |
3. | ALA4134891 | B | Inhibition of EGFP-tagged Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in BAPTA-induced calcium release activated calcium channel currents at 2 uM after 30 to 60 mins by whole cell patch clamp method | Homo sapiens | 1 | ALA4130479 | cell-based format | Scientific Literature | |
4. | ALA4158686 | B | Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as reduction in store-operated calcium currents at 10 uM by patch clamp assay relative to control | Homo sapiens | 1 | ALA4152384 | cell-based format | Scientific Literature | |
5. | ALA4158738 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA by patch clamp assay relative to control | Homo sapiens | 2 | ALA4152384 | cell-based format | Scientific Literature | |
6. | ALA4158739 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA and 150 nM Ca2+ containing internal solution by patch clamp assay relative to control | Homo sapiens | 2 | ALA4152384 | cell-based format | Scientific Literature | |
7. | ALA4678371 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response at 10 uM relative to control | Homo sapiens | 42 | ALA4673335 | cell-based format | Scientific Literature | |
8. | ALA4678373 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Homo sapiens | 11 | ALA4673335 | cell-based format | Scientific Literature | |
9. | ALA4678374 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in calcium entry AUC at 10 uM relative to control | Homo sapiens | 10 | ALA4673335 | cell-based format | Scientific Literature | |
10. | ALA4678375 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in peak amplitude of calcium entry at 10 uM relative to control | Homo sapiens | 10 | ALA4673335 | cell-based format | Scientific Literature | |
11. | ALA4678376 | B | Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in peak amplitude of calcium entry at 10 uM relative to control | Homo sapiens | 1 | ALA4673335 | cell-based format | Scientific Literature | |
12. | ALA4678377 | B | Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in AUC of calcium entry at 10 uM relative to control | Homo sapiens | 1 | ALA4673335 | cell-based format | Scientific Literature | |
13. | ALA4678378 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in slope of calcium entry at 10 uM relative to control | Homo sapiens | 9 | ALA4673335 | cell-based format | Scientific Literature | |
14. | ALA4714763 | A | Inhibition of STIM/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in thapsigargin-induced Ca2+ influx at 10 uM in presence of Ca2+ by whole cell patch clamp method | Homo sapiens | 2 | ALA4706728 | cell-based format | Scientific Literature | |
15. | ALA4722524 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 2 uM by whole cell patch clamp electrophysiological method | Homo sapiens | 1 | ALA4715835 | cell-based format | Scientific Literature | |
16. | ALA4834160 | B | Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual patch clamp based electrophysiological method | Homo sapiens | 2 | ALA4831556 | cell-based format | Scientific Literature | |
17. | ALA4834161 | B | Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 100 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control | Homo sapiens | 1 | ALA4831556 | cell-based format | Scientific Literature | |
18. | ALA4834162 | B | Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 300 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control | Homo sapiens | 1 | ALA4831556 | cell-based format | Scientific Literature | |
19. | ALA4834199 | B | Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological method | Homo sapiens | 1 | ALA4831556 | cell-based format | Scientific Literature | |
20. | ALA4834201 | B | Inhibition of Orai1/STIM1 (unknown origin) | Homo sapiens | 1 | ALA4831556 | protein complex format | Scientific Literature |