| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3734545 | B | Inhibition of recombinant human STIM1/Orai1 expressed in HEK293 cells assessed as inhibition of peak basal signal after 30 mins by fluo4-AM dye-based FLIPR assay | Homo sapiens | 78 | cell-based format | Patent Bioactivity Data | ||
| 2. | ALA3734079 | F | Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as intracellular calcium level after 30 mins by FLIPR assay | Homo sapiens | 65 | cell-based format | Patent Bioactivity Data | ||
| 3. | ALA4134891 | B | Inhibition of EGFP-tagged Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in BAPTA-induced calcium release activated calcium channel currents at 2 uM after 30 to 60 mins by whole cell patch clamp method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4158686 | B | Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as reduction in store-operated calcium currents at 10 uM by patch clamp assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4158738 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA by patch clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4158739 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA and 150 nM Ca2+ containing internal solution by patch clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4678371 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response at 10 uM relative to control | Homo sapiens | 42 | cell-based format | Scientific Literature | ||
| 8. | ALA4678373 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 9. | ALA4678374 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in calcium entry AUC at 10 uM relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 10. | ALA4678375 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in peak amplitude of calcium entry at 10 uM relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
| 11. | ALA4678376 | B | Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in peak amplitude of calcium entry at 10 uM relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4678377 | B | Activation of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as increase in tBHQ-induced calcium response by measuring increase in AUC of calcium entry at 10 uM relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4678378 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in tBHQ-induced calcium response by measuring decrease in slope of calcium entry at 10 uM relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 14. | ALA4714763 | A | Inhibition of STIM/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in thapsigargin-induced Ca2+ influx at 10 uM in presence of Ca2+ by whole cell patch clamp method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4722524 | B | Inhibition of STIM1/Orai1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 2 uM by whole cell patch clamp electrophysiological method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4834160 | B | Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual patch clamp based electrophysiological method | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4834161 | B | Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 100 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4834162 | B | Reversible inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current at 300 nM preincubated with compound followed by washout for 4 hrs by manual patch clamp based electrophysiological method relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4834199 | B | Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4834201 | B | Inhibition of Orai1/STIM1 (unknown origin) | Homo sapiens | 1 | protein complex format | Scientific Literature |
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