| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4122666 | B | Stabilization of 5'-FAM/3'-TAMRA labeled human F21T G-quadruplex DNA assessed as change in melting temperature at 0.5 uM by FRET assay | Homo sapiens | 3 | nucleic acid format | Scientific Literature | ||
| 2. | ALA4122667 | B | Stabilization of 5'-FAM/3'-TAMRA labeled c-KIT1 G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 0.5 uM by FRET assay | Not specified | 3 | nucleic acid format | Scientific Literature | ||
| 3. | ALA4122668 | B | Stabilization of 5'-FAM/3'-TAMRA labeled c-KIT2 G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 0.5 uM by FRET assay | Not specified | 3 | nucleic acid format | Scientific Literature | ||
| 4. | ALA4122669 | B | Stabilization of 5'-FAM/3'-TAMRA labeled BCL-2 promoter G-quadruplex DNA (unknown origin) assessed as change in melting temperature at 0.5 uM by FRET assay | Not specified | 3 | nucleic acid format | Scientific Literature | ||
| 5. | ALA4122682 | B | Stabilization of c-KIT G-quadruplex DNA in imatinib-resistant human GIST48 cells harboring c-KIT V560D/D820A double mutant assessed as downregulation of c-KIT protein expression at 1 uM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 6. | ALA4122683 | B | Stabilization of c-KIT G-quadruplex DNA in imatinib-resistant human GIST48 cells harboring c-KIT V560D/D820A double mutant assessed as downregulation of c-KIT protein expression at 1 uM after 1 week by immunoblot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 7. | ALA4122684 | B | Stabilization of c-KIT G-quadruplex DNA in imatinib-susceptible human GIST882 cells harboring c-KIT K642E mutant assessed as downregulation of c-KIT protein expression at 1 uM after 24 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 8. | ALA4124091 | B | Binding affinity to human telomeric G-quadruplex DNA in K+ buffer at 9.4 uM by UV-vis titration analysis | Homo sapiens | 1 | nucleic acid format | Scientific Literature | ||
| 9. | ALA4124092 | F | Alkylating activity at human telomeric G-quadruplex DNA in K+ buffer assessed as thermal stabilization by measuring change in melting temperature at 1.5 uM by circular dichroism spectral analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 10. | ALA4124093 | F | Alkylating activity at 12T base of human telomeric G-quadruplex DNA in K+ buffer at 100 uM using 9-mer primer after 72 hrs by primer extension method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 11. | ALA4124094 | F | Alkylating activity at 5'-FAM-labeled human telomeric G-quadruplex DNA in K+ buffer at 100 uM measured up to 72 hrs by PAGE analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 12. | ALA4124096 | F | Alkylating activity at 5'-FAM-labeled human telomeric G-quadruplex DNA at 100 uM in Na+ buffer measured up to 72 hrs by PAGE analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 13. | ALA4124098 | B | Binding affinity to human telomeric G-quadruplex DNA in K+ buffer at 0.2 uM after 15 mins by spectrofluorometric method | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 14. | ALA4124100 | B | Binding affinity to human telomeric G-quadruplex DNA in Na+ buffer at 0.2 uM after 15 mins by spectrofluorometric method | Homo sapiens | 2 | nucleic acid format | Scientific Literature | ||
| 15. | ALA4124101 | B | Binding affinity to human telomeric G-quadruplex DNA in Na+ buffer at 9.4 uM UV-vis titration analysis | Homo sapiens | 1 | nucleic acid format | Scientific Literature | ||
| 16. | ALA4124102 | B | Effect on conformation of human telomeric G-quadruplex DNA in K+ buffer by circular dichroism spectral analysis | Homo sapiens | 1 | nucleic acid format | Scientific Literature | ||
| 17. | ALA4124103 | B | Effect on conformation of human telomeric G-quadruplex DNA in Na+ buffer by circular dichroism spectral analysis | Homo sapiens | 1 | nucleic acid format | Scientific Literature | ||
| 18. | ALA4124104 | F | Alkylating activity at human telomeric G-quadruplex DNA in Na+ buffer assessed as thermal stabilization by measuring change in melting temperature at 1.5 uM by circular dichroism spectral analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 19. | ALA4124105 | F | Alkylating activity at 13T base of human telomeric G-quadruplex DNA in K+ buffer at 100 uM using 9-mer primer after 72 hrs by primer extension method | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 20. | ALA4124106 | F | Alkylating activity at 14G base of human telomeric G-quadruplex DNA in K+ buffer at 100 uM using 9-mer primer after 72 hrs by primer extension method | Homo sapiens | 1 | assay format | Scientific Literature |
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