# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3863933 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit | Shigella dysenteriae | 23 | ALA3862035 | single protein format | Scientific Literature | |
2. | ALA3863934 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit assessed as change in transition temperature by SYPRO orange dye based fluorescence-based thermal shift assay | Shigella dysenteriae | 20 | ALA3862035 | single protein format | Scientific Literature | |
3. | ALA3863936 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay relative to untreated control | Shigella dysenteriae | 6 | ALA3862035 | cell-based format | Scientific Literature | |
4. | ALA3863937 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by MTT assay relative to untreated control | Shigella dysenteriae | 6 | ALA3862035 | cell-based format | Scientific Literature | |
5. | ALA3863938 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control | Shigella dysenteriae | 6 | ALA3862035 | cell-based format | Scientific Literature | |
6. | ALA3863939 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as protection of cell membrane integrity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by LDH release assay relative to untreated control | Shigella dysenteriae | 6 | ALA3862035 | cell-based format | Scientific Literature | |
7. | ALA3863940 | B | Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity pre-treated with compound for 1 hr followed by Stx exposure for 24 hrs by neutral red uptake assay | Shigella dysenteriae | 9 | ALA3862035 | cell-based format | Scientific Literature | |
8. | ALA3863942 | B | Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit by SPR method | Shigella dysenteriae | 1 | ALA3862035 | single protein format | Scientific Literature | |
9. | ALA3863943 | B | Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast on rate constant by SPR method | Shigella dysenteriae | 1 | ALA3862035 | single protein format | Scientific Literature | |
10. | ALA3863944 | B | Binding affinity to recombinant Shigella dysenteriae type 1 Shiga toxin A subunit assessed as fast off rate constant by SPR method | Shigella dysenteriae | 1 | ALA3862035 | single protein format | Scientific Literature |