| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3803169 | B | Inhibition of MNK1/2 in human KMS11-luc cells assessed as inhibition of EIF4E phosphorylation at S209 after 3 hrs by quantitative electrochemiluminescence assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA3806741 | B | Inhibition of MNK1/MNK2 in human HeLa cells assessed as reduction in phosphorylation of eIF4E at Ser209 after 2 hrs by AlphaScreen SureFire assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 3. | ALA3806817 | B | Inhibition of MNK1/MNK2 in human K562 cells over expressing eIF4E assessed as reduction in phosphorylation of eIF4E at Ser209 after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4048641 | B | Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA4048670 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by immunoblot method | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4048674 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in IL-6 levels after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4048675 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in IL-8 levels after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4048676 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in TNF-alpha levels after 48 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4048677 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in TNF-alpha mRNA half life at 10 uM incubated for 24 hrs by TaqMan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4048678 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in IL-6 mRNA half life at 10 uM incubated for 24 hrs by TaqMan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4048679 | B | Inhibition of MNK1/2 in human TMD8 cells assessed as decrease in IL-8 mRNA half life at 10 uM incubated for 24 hrs by TaqMan assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4189498 | B | Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 13. | ALA4236040 | B | Inhibition of MNK1/MNK2 in human HCT116 cells assessed as reduction in eIF4E phosphorylation at Ser209 residue after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4331739 | B | Inhibition of MNK in human PBMC assessed as reduction in eIF4E phosphorylation at 200 mg after 24 hrs relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 15. | ALA4331740 | B | Inhibition of MNK in human PBMC assessed as reduction in eIF4E phosphorylation at 20 mg after 24 hrs relative to control | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 16. | ALA4350474 | B | Inhibition of MNK in human A2780 cells assessed as reduction in phosphorylated eIF4E at Ser209 at 10 to 40 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4380948 | B | Inhibition of MNK1/MNK2 in human HeLa cells overexpressing eIF4E assessed as reduction in eIF4E phosphorylation at Ser209 residue after 2 hrs by Alphascreen SureFly assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 18. | ALA4384672 | B | Inhibition of MNK in human MDA-MB-231 cells assessed as decrease in eIF4E phosphorylation at 1 uM after 2 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4384681 | B | Inhibition of MNK in human MDA-MB-231 cells assessed as decrease in eIF4E phosphorylation at 3 uM up to 72 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4666418 | B | Inhibition of MNK1/MNK2 in human CT26 cells assessed as reduction in eIF4E phosphorylation at 1 uM incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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