| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA1819960 | B | Inhibition of recombinant human p300/CBP using [3H]-acetyl CoA at 50 uM after 2 hrs by scintillation counting relative to control | Homo sapiens | 10 | protein format | Scientific Literature | ||
| 2. | ALA1227295 | B | Binding affinity to human p300/CBP using [14C]acetyl-CoA by slow binding inhibition assay | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 3. | ALA3391512 | B | Inhibition of recombinant p300/CBP (unknown origin) expressed in baculovirus expression system using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 4. | ALA3817198 | B | Inhibition of CBP/EP300 in human AMO1 cells assessed as reduction in MYC expression after 6 hrs by quantigene plex assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA3863192 | B | Inhibition of human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 assessed as change in melting temperature at 10 uM by SYPRO orange dye-based differential scanning fluorimetry | Homo sapiens | 96 | assay format | Scientific Literature | ||
| 6. | ALA3863194 | B | Binding affinity to human CBP/P300 expressed in Escherichia coli BL21(DE3)-R3 by isothermal titration calorimetry | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 7. | ALA3863197 | B | Inhibition of chromatin binding to GFP-fused CBP/P300 (unknown origin) expressed in SAHA treated human U2OS cells assessed as decrease in recovery half life at 1 uM by FRAP assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA3863198 | B | Binding affinity to human N-terminal His10-tagged/C-terminal Biotin-tagged CBP (R1081 to G1198 residues)/P300 expressed in Escherichia coli BL21(DE3)-R3-BirA by isothermal titration calorimetry | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 9. | ALA3864387 | B | Inhibition of CBP/EP300 (unknown origin) assessed as reduction in MYC expression by cell based assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA3864389 | B | Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay | Homo sapiens | 52 | protein format | Scientific Literature | ||
| 11. | ALA3864392 | B | Inhibition of Halo-tagged histone H3.3 binding to CBP/EP300 (unknown origin) expressed in HEK293 cells measured after overnight incubation by luciferase reporter gene based BRET assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 12. | ALA3864398 | B | Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA3864425 | B | Inhibition of CBP/EP300 in human MOLM16 cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA3864426 | B | Inhibition of CBP/EP300 in human HL60 cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA3864427 | B | Inhibition of CBP/EP300 in human LP-1 cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA3864428 | B | Inhibition of CBP/EP300 in human KMS34 cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA3864429 | B | Inhibition of CBP/EP300 in human Pfeiffer cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA3864430 | B | Inhibition of CBP/EP300 in human DOHH2 cells assessed as decrease in MYC expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA3864431 | B | Inhibition of CBP/EP300 in human MOLM16 cells assessed as suppression of MYB expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA3864432 | B | Inhibition of CBP/EP300 in human MOLM16 cells assessed as suppression of CCND1 expression at 5 uM measured after 4 hrs by RT-PCR analysis relative to DMSO control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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