# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3803421 | B | Binding affinity to CDK8/CDK19 in human 7dF3 cells preincubated for 2 hrs followed by addition 10 uM of beta-oestradiol measured after 24 hrs by luciferase reporter gene assay | Homo sapiens | 55 | cell-based format | Scientific Literature | ||
2. | ALA4805242 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of MYC expression as percent of control at 1 uM by QPCR assay relative to control | Homo sapiens | 5 | tissue-based format | Patent Bioactivity Data | ||
3. | ALA4805243 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of CXCL1 expression as percent of control at 1 uM by QPCR assay relative to control | Homo sapiens | 5 | tissue-based format | Patent Bioactivity Data | ||
4. | ALA4805244 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of IL-8 expression as percent of control at 1 uM by QPCR assay relative to control | Homo sapiens | 5 | tissue-based format | Patent Bioactivity Data | ||
5. | ALA4805245 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of MYC expression by QPCR assay | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
6. | ALA4805246 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of CXCL1 expression by QPCR assay | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
7. | ALA4805247 | B | Inhibition of CDK8/CDK19 in TNF-alpha-induced HEK293 cells assessed as inhibition of IL-8 expression by QPCR assay | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
8. | ALA4805251 | B | Inhibition of CDK8/CDK19 in HEK293 cells assessed as reduction in JUN expression at 1 uM incubated for 2 hrs and measured after 24 hrs of compound wash-off | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4805252 | B | Inhibition of CDK8/CDK19 in HEK293 cells assessed as reduction in MYC expression at 1 uM incubated for 2 hrs and measured after 24 hrs of compound wash-off | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4805264 | B | Inhibition of CDK8/CDK19 in HEK293 cells by NF-kappaB reporter assay | Homo sapiens | 5 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4806367 | B | Inhibition of CDK8/CDK19 in HEK293 cells by NF-kappaB reporter assay | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4806368 | B | Inhibition of CDK8/CDK19 in CDK8 and CDK19-knockout HEK293 cells by NF-kappaB reporter assay | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
13. | ALA4806369 | B | Inhibition of CDK8/CDK19 in ST2 cells by alkaline phosphatase activity assay | Homo sapiens | 6 | cell-based format | Patent Bioactivity Data |