# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4040293 | B | Inhibition of tunicamycin ER stress-induced ATF6 activation in rat INS-1 cells assessed as suppression of increase in Bip mRNA levels up to 10 uM after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
2. | ALA4040294 | B | Inhibition of tunicamycin ER stress-induced ATF6 activation in rat INS-1 cells assessed as suppression of increase in GPR94 mRNA levels up to 10 uM after 8 hrs by qRT-PCR analysis | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
3. | ALA4344938 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
4. | ALA4344949 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM using compound pre-activated with hydrogen peroxide for 8 hrs prior to NRVM treatment and measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
5. | ALA4344950 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in GRP78 expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
6. | ALA4344951 | B | Activation of ATF6 in NRVM isolated from Sprague-Dawley rat assessed as increase in catalase expression at 10 uM measured after 16 hrs by SYBR green dye-based qRT-PCR analysis | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
7. | ALA4344953 | B | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs by LDH assay | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
8. | ALA4344954 | B | Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawley rat assessed as increase in cell viability by measuring media LDH content at 10 uM followed by ischemia simulation for 8 hrs and subsequent reperfusion and compound treatment for 24 hrs under normoxia condition by calcein-AM green dye based fluorescence microscopy | Rattus norvegicus | 2 | single protein format | Scientific Literature | ||
9. | ALA4429058 | B | Inhibition of ATF6 in rat INS-1 cells assessed as suppression of tunicamycin induced Bip mRNA levels at 20 uM after 4 to 24 hrs by qRT-PCR method | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
10. | ALA4429059 | B | Inhibition of ATF6 in rat INS-1 cells assessed as suppression of tunicamycin induced GRP94 mRNA levels at 20 uM after 4 to 24 hrs by qRT-PCR method | Rattus norvegicus | 1 | cell-based format | Scientific Literature |