# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4037315 | B | Agonist activity at mincle in wild type C57BL/6 mouse GM-CSF derived BMDM assessed as increase in IL-6 release at 0.1 to 1 nmol after 24 hrs by sandwich ELISA | Mus musculus | 11 | ALA4033780 | single protein format | Scientific Literature | |
2. | ALA4037316 | B | Agonist activity at mincle in wild type C57BL/6 mouse GM-CSF derived BMDM assessed as increase in IL-1beta release at 0.1 to 1 nmol after 24 hrs by sandwich ELISA | Mus musculus | 11 | ALA4033780 | single protein format | Scientific Literature | |
3. | ALA4037317 | B | Agonist activity at mincle in wild type C57BL/6 mouse GM-CSF derived BMDM assessed as increase in MIP2 release at 0.1 to 1 nmol after 24 hrs by sandwich ELISA | Mus musculus | 11 | ALA4033780 | single protein format | Scientific Literature | |
4. | ALA4037318 | B | Agonist activity at mincle in wild type C57BL/6 mouse GM-CSF derived BMDM assessed as increase in TNF release at 0.1 to 1 nmol after 24 hrs by sandwich ELISA | Mus musculus | 11 | ALA4033780 | single protein format | Scientific Literature | |
5. | ALA4037320 | B | Binding affinity to recombinant mouse mincle extracellular domain fused with human IgG Fc expressed in HEK293T cells at 0.1 nmol by ELISA | Mus musculus | 9 | ALA4033780 | cell-based format | Scientific Literature | |
6. | ALA4037324 | B | Agonist activity at mouse mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells after 18 hrs by flow cytometric analysis | Mus musculus | 3 | ALA4033780 | cell-based format | Scientific Literature | |
7. | ALA4037326 | B | Agonist activity at mouse mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells at higher concentration after 18 hrs by flow cytometric analysis | Mus musculus | 1 | ALA4033780 | cell-based format | Scientific Literature | |
8. | ALA4037335 | B | Agonist activity at mouse mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells up to 1 nmol after 18 hrs by flow cytometric analysis | Mus musculus | 4 | ALA4033780 | cell-based format | Scientific Literature | |
9. | ALA4379968 | B | Agonist activity at Mincle in mouse RAW264.7 cells assessed as TNF-alpha secretion at 0.1 to 100 uM incubated for 18 to 24 hrs by ELISA | Mus musculus | 4 | ALA4376847 | cell-based format | Scientific Literature | |
10. | ALA4379969 | B | Agonist activity at Mincle in mouse RAW264.7 cells assessed as IL-6 production at 0.1 to 100 uM incubated for 18 to 24 hrs by ELISA | Mus musculus | 4 | ALA4376847 | cell-based format | Scientific Literature | |
11. | ALA4379972 | B | Agonist activity at mouse Mincle receptor expressed in human HEK cells assessed as NF-kappaB activation incubated for 24 hrs by SEAP reporter gene assay | Mus musculus | 3 | ALA4376847 | cell-based format | Scientific Literature | |
12. | ALA4385465 | B | Agonist activity at mouse mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells at 3 nmol/well after 16 hrs by flow cytometric analysis | Mus musculus | 15 | ALA4382288 | cell-based format | Scientific Literature | |
13. | ALA5238059 | B | Induction of mouse Mincle expressed in NFAT-GFP reporter cells assessed as induction of mincle-mediated NFAT signaling activity by measuring stimulation of GFP reporter activity at 0.1 nmol/well incubated for 18 hrs by flow cytometry | Mus musculus | 3 | ALA5236582 | cell-based format | Scientific Literature | |
14. | ALA5238061 | B | Induction of mouse Mincle expressed in NFAT-GFP reporter cells assessed as induction of mincle-mediated NFAT signaling activity by measuring stimulation of GFP reporter activity at 0.001 to 0.1 nmol/well incubated for 18 hrs by flow cytometry | Mus musculus | 10 | ALA5236582 | cell-based format | Scientific Literature |