| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3992331 | B | Binding affinity to Rab7 GTPase L129F mutant (unknown origin) assessed as equilibrium dissociation constant | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
| 2. | ALA3992332 | B | Binding affinity to wild-type Rab7 (unknown origin) assessed as equilibrium dissociation constant | Homo sapiens | 2 | single protein format | Patent Bioactivity Data | ||
| 3. | ALA3992333 | B | Binding affinity to Rab7 GTPase V162M mutant (unknown origin) assessed as equilibrium dissociation constant | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
| 4. | ALA3992334 | B | Displacement of GDP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 40 to 45 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 5. | ALA3992335 | B | Displacement of RILP from GTP bound wild-type His-tagged Rab7 GTPase (unknown origin) | Homo sapiens | 1 | single protein format | Patent Bioactivity Data | ||
| 6. | ALA3992336 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 40 to 45 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 7. | ALA3992337 | B | Displacement of 400 nM OF BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM after 2 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 8. | ALA3992338 | B | Displacement of 200 nM OF BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM after 2 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 9. | ALA3992339 | B | Displacement of 100 nM OF BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM after 2 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 10. | ALA3992340 | B | Displacement of 50 nM OF BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) at 10 uM after 2 mins by FACScan flow cytometry | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
| 11. | ALA3992341 | B | Increase in membrane localization of Rab7 in human HeLa cells at 10 uM by immunofluorescence assay | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 12. | ALA3992342 | B | Inhibition of Rab7 in human SCC-12F cells assessed as reduction in EGF induced EGFR lysosomal degradation preincubated for 30 mins followed by EGF addition measured after 15 to 180 mins by SDS-PAGE | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 13. | ALA3992343 | B | Inhibition of wild-type GFP-tagged Rab7 in human HeLa cell lysate assessed as reduction in EGF induced EGFR lysosomal degradation at 10 to 100 uM preincubated for 3 hrs followed by EGF addition measured after 15 to 120 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
| 14. | ALA3992344 | B | Binding affinity to Rab7 GTPase N161T mutant (unknown origin) assessed as equilibrium dissociation constant | Homo sapiens | 2 | assay format | Patent Bioactivity Data | ||
| 15. | ALA3992359 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in EDTA buffer after 2 hrs by flow cytometry | Homo sapiens | 22 | assay format | Patent Bioactivity Data | ||
| 16. | ALA3992360 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in EDTA buffer assessed as residual activity after 2 hrs by flow cytometry | Homo sapiens | 22 | assay format | Patent Bioactivity Data | ||
| 17. | ALA3992361 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in Mg buffer after 2 hrs by flow cytometry | Homo sapiens | 22 | assay format | Patent Bioactivity Data | ||
| 18. | ALA3992362 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) in Mg buffer assessed as residual activity after 2 hrs by flow cytometry | Homo sapiens | 21 | assay format | Patent Bioactivity Data | ||
| 19. | ALA3992363 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 2 hrs by flow cytometry | Homo sapiens | 7 | assay format | Patent Bioactivity Data | ||
| 20. | ALA3992369 | B | Displacement of BODIPY-GTP from nucleotide binding site of wild-type GST-tagged Rab7 GTPase (unknown origin) expressed in Escherichia coli BL21(DE3) after 2 hrs by flow cytometry relative to untreated control | Homo sapiens | 3 | assay format | Patent Bioactivity Data |
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