# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418216 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p70 phosphorylation incubated for 6 hrs by Western blot analysis | Homo sapiens | 9 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
2. | ALA4418222 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p70 phosphorylation at 0.5 uM incubated for 6 hrs by Western blot analysis relative to Perchlorocyclopenta-2,4-dien-1-ylidene)hydrazine | Homo sapiens | 29 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
3. | ALA4418224 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p21 expression at 0.5 to 2 uM uM by Western blot analysis | Homo sapiens | 3 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
4. | ALA4418225 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as increase in mTOR kinase activity by measuring induction of p21 expression at 0.25 to 1 uM uM by Western blot analysis | Homo sapiens | 2 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
5. | ALA4418229 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as induction of mTORC1 activation at 1 uM incubated for 6 hrs co-immunoprecipitation assay | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
6. | ALA4418230 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as induction of mTORC1 activation at 0.5 uM incubated for 6 hrs co-immunoprecipitation assay | Homo sapiens | 4 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
7. | ALA4418236 | Binding | Induction of proteasome-dependent DEPTOR degradation in human RPMI8226 cells at 0.5 to 2 uM | Homo sapiens | 1 | ALA4417640 | cell-based format | Patent Bioactivity Data | |
8. | ALA4047126 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC2-associated AKT phosphorylation at S473 residue by Western blot analysis | Homo sapiens | 2 | ALA4043223 | cell-based format | Scientific Literature | |
9. | ALA4047127 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 1 to 2 uM after 6 hrs by Western blot analysis | Homo sapiens | 9 | ALA4043223 | cell-based format | Scientific Literature | |
10. | ALA4047129 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.5 uM after 6 hrs by Western blot analysis | Homo sapiens | 8 | ALA4043223 | cell-based format | Scientific Literature | |
11. | ALA4047130 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.05 to 0.2 uM after 6 hrs by Western blot analysis | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
12. | ALA4047133 | Binding | Inhibition of DEPTOR in human RPMI8226 cells assessed as upregulation of mTORC1-dependant p21 expression at 0.5 to 2 uM after 6 hrs by Western blot analysis | Homo sapiens | 4 | ALA4043223 | cell-based format | Scientific Literature | |
13. | ALA4047134 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.5 uM after 6 hrs by Western blot analysis relative to NSC126405 | Homo sapiens | 28 | ALA4043223 | cell-based format | Scientific Literature | |
14. | ALA4047137 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated p70 phosphorylation at 0.25 uM after 6 hrs by Western blot analysis | Homo sapiens | 5 | ALA4043223 | cell-based format | Scientific Literature | |
15. | ALA4047141 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells at 1 uM treated 6 hrs followed by DEPTOR immunoprecipitation by immunoblotting analysis | Homo sapiens | 1 | ALA4043223 | cell-based format | Scientific Literature | |
16. | ALA4047142 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells at 0.5 uM treated 6 hrs followed by DEPTOR immunoprecipitation by immunoblotting analysis | Homo sapiens | 4 | ALA4043223 | cell-based format | Scientific Literature | |
17. | ALA4047146 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated 4E-BP1 phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4043223 | cell-based format | Scientific Literature | |
18. | ALA4047147 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC1-associated S6 phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4043223 | cell-based format | Scientific Literature | |
19. | ALA4047148 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as increase in mTORC2-associated SGK phosphorylation by Western blot analysis | Homo sapiens | 2 | ALA4043223 | cell-based format | Scientific Literature | |
20. | ALA4047149 | Binding | Inhibition of mTOR binding to DEPTOR in human RPMI8226 cells assessed as decrease in AKT phosphorylation at ser308 residue by Western blot analysis | Homo sapiens | 2 | ALA4043223 | cell-based format | Scientific Literature |