# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4037321 | B | Binding affinity to recombinant human mincle extracellular domain fused with human IgG Fc expressed in HEK293T cells at 0.1 nmol by ELISA | Homo sapiens | 9 | ALA4033780 | cell-based format | Scientific Literature | |
2. | ALA4037322 | B | Agonist activity at human mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells up to 1 nmol after 18 hrs by flow cytometric analysis | Homo sapiens | 2 | ALA4033780 | cell-based format | Scientific Literature | |
3. | ALA4037323 | B | Agonist activity at human mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells after 18 hrs by flow cytometric analysis | Homo sapiens | 3 | ALA4033780 | cell-based format | Scientific Literature | |
4. | ALA4037325 | B | Agonist activity at human mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells at higher concentration after 18 hrs by flow cytometric analysis | Homo sapiens | 2 | ALA4033780 | cell-based format | Scientific Literature | |
5. | ALA4037331 | B | Agonist activity at human mincle R183A mutant expressed in NFAT-GFP reporter cells up to 3000 pmol after 18 hrs by flow cytometric analysis | Homo sapiens | 2 | ALA4033780 | cell-based format | Scientific Literature | |
6. | ALA4379963 | B | Agonist activity at Mincle in human PBMC assessed as increase in TNF-alpha production at 1 to 1000 uM incubated for 18 to 24 hrs by ELISA | Homo sapiens | 5 | ALA4376847 | single protein format | Scientific Literature | |
7. | ALA4379964 | B | Agonist activity at Mincle in human PBMC assessed as increase in IL-6 secretion at 0.1 to 100 uM incubated for 18 to 24 hrs by luminex multiplex assay | Homo sapiens | 5 | ALA4376847 | single protein format | Scientific Literature | |
8. | ALA4379965 | B | Agonist activity at Mincle in human PBMC assessed as increase in IL-1beta secretion at 0.1 to 100 uM incubated for 18 to 24 hrs by luminex multiplex assay | Homo sapiens | 5 | ALA4376847 | single protein format | Scientific Literature | |
9. | ALA4379966 | B | Agonist activity at Mincle in human PBMC assessed as increase in IL-23 at 0.1 to 100 uM incubated for 18 to 24 hrs by luminex multiplex assay | Homo sapiens | 5 | ALA4376847 | single protein format | Scientific Literature | |
10. | ALA4379967 | B | Agonist activity at Mincle in human PBMC assessed as increase in TNF-alpha level at 0.1 to 100 uM incubated for 18 to 24 hrs by luminex multiplex assay | Homo sapiens | 5 | ALA4376847 | single protein format | Scientific Literature | |
11. | ALA4379970 | B | Agonist activity at Mincle in human PBMC assessed as TNF-alpha secretion at 0.1 to 100 uM incubated for 18 to 24 hrs by ELISA | Homo sapiens | 4 | ALA4376847 | single protein format | Scientific Literature | |
12. | ALA4379971 | B | Agonist activity at human Mincle receptor expressed in human HEK cells assessed as NF-kappaB activation incubated for 24 hrs by SEAP reporter gene assay | Homo sapiens | 3 | ALA4376847 | cell-based format | Scientific Literature | |
13. | ALA4385464 | B | Agonist activity at human mincle coupled with FcRgamma expressed in 2B4-NFAT-GFP reporter cells at 3 nmol/well after 16 hrs by flow cytometric analysis | Homo sapiens | 14 | ALA4382288 | cell-based format | Scientific Literature | |
14. | ALA4624989 | B | Agonist activity at human Mincle receptor expressed in HEK cells cotransfected with NF-kappaB SEAP reporter gene assessed as increase in production of SEAP measured after 18 to 24 hrs by SEAP reporter gene-based spectrophotometric method | Homo sapiens | 4 | ALA4622927 | cell-based format | Scientific Literature | |
15. | ALA4624990 | B | Agonist activity at human Mincle receptor expressed in HEK cells cotransfected with NF-kappaB SEAP reporter gene assessed as increase in production of SEAP at 20 uM measured after 18 to 24 hrs by SEAP reporter gene-based spectrophotometric method | Homo sapiens | 1 | ALA4622927 | cell-based format | Scientific Literature | |
16. | ALA4726083 | B | Agonist activity at human Mincle receptor up to 10 uM | Homo sapiens | 1 | ALA4725242 | single protein format | Scientific Literature | |
17. | ALA5238058 | B | Induction of human Mincle expressed in NFAT-GFP reporter cells assessed as induction of mincle-mediated NFAT signaling activity by measuring stimulation of GFP reporter activity at 0.1 nmol/well incubated for 18 hrs by flow cytometry | Homo sapiens | 3 | ALA5236582 | cell-based format | Scientific Literature | |
18. | ALA5238060 | B | Induction of human Mincle expressed in NFAT-GFP reporter cells assessed as induction of mincle-mediated NFAT signaling activity by measuring stimulation of GFP reporter activity at 0.001 to 0.1 nmol/well incubated for 18 hrs by flow cytometry | Homo sapiens | 10 | ALA5236582 | cell-based format | Scientific Literature |