# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4032674 | B | Agonist activity at FXR in rat primary hepatocytes assessed as induction of BSEP mRNA level after 24 hrs by qPCR analysis | Rattus norvegicus | 1 | ALA4028903 | cell-based format | Scientific Literature | |
2. | ALA4032675 | B | Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level after 24 hrs by qPCR analysis | Rattus norvegicus | 1 | ALA4028903 | cell-based format | Scientific Literature | |
3. | ALA4032676 | B | Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level at 10 nM after 24 hrs by qPCR analysis relative to control | Rattus norvegicus | 1 | ALA4028903 | cell-based format | Scientific Literature | |
4. | ALA4032677 | B | Agonist activity at FXR in rat primary hepatocytes assessed as induction of SHP mRNA level at 1 nM after 24 hrs by qPCR analysis relative to control | Rattus norvegicus | 1 | ALA4028903 | cell-based format | Scientific Literature | |
5. | ALA4056014 | B | Agonist activity at FXR in rat primary hepatocytes | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
6. | ALA4056015 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in BSEP mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
7. | ALA4056016 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in SHP mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
8. | ALA4056017 | B | Agonist activity at FXR in rat primary hepatocytes assessed as reduction in CYP7A1 mRNA expression at 50 uM | Rattus norvegicus | 2 | ALA4052684 | cell-based format | Scientific Literature | |
9. | ALA4404140 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in SHP mRNA level incubated for 24 hrs by qRT-PCR analysis relative to tropifexor | Rattus norvegicus | 1 | ALA4402557 | cell-based format | Scientific Literature | |
10. | ALA4404142 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in BSEP mRNA level incubated for 24 hrs by qRT-PCR analysis relative to tropifexor | Rattus norvegicus | 1 | ALA4402557 | cell-based format | Scientific Literature | |
11. | ALA4404143 | B | Agonist activity at FXR in rat primary hepatocytes assessed as increase in BSEP mRNA level incubated for 24 hrs by qRT-PCR analysis relative to DMSO | Rattus norvegicus | 1 | ALA4402557 | cell-based format | Scientific Literature | |
12. | ALA5157335 | F | In vivo activation of FXR in male Sprague-Dawley rat assessed as fold increase in FGF15 level at 5 mg/kg, po administered once daily for 14 days measured at 6 hrs by ELISA | Rattus norvegicus | 1 | ALA5154690 | organism-based format | Scientific Literature | |
13. | ALA5157336 | F | In vivo activation of FXR in male Sprague-Dawley rat assessed as fold increase in ileum FGF15 level at 5 mg/kg, po administered as single dose measured at 1 hr by RT-qPCR assay | Rattus norvegicus | 1 | ALA5154690 | organism-based format | Scientific Literature | |
14. | ALA5157337 | F | In vivo activation of FXR in male Sprague-Dawley rat assessed as fold increase in liver BSEP level at 5 mg/kg, po administered as single dose measured at 1 hr by RT-qPCR assay | Rattus norvegicus | 1 | ALA5154690 | organism-based format | Scientific Literature |