# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4028573 | B | Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assay | Homo sapiens | 13 | ALA4024800 | assay format | Scientific Literature | |
2. | ALA4028574 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in intracellular NAD+ levels at 5 uM after 48 hrs by NAD/NADH-Glo assay | Homo sapiens | 2 | ALA4024800 | cell-based format | Scientific Literature | |
3. | ALA4418029 | B | Inhibition of human recombinant ACMSD1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in conversion of 3-OH-anthranilic acid into ACMS by spectrophotometry | Homo sapiens | 22 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
4. | ALA4418030 | B | Inhibition of human recombinant ACMSD1 expressed in HEK293T cells assessed as reduction in conversion of 3-OH-anthranilic acid into ACMS by spectrophotometry | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
5. | ALA4418031 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 0.5 uM following compound replacement every 24 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
6. | ALA4418032 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 5 uM following compound replacement every 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
7. | ALA4418033 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 500 uM following compound replacement every 24 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
8. | ALA4418034 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD concentration at 250 uM following compound replacement every 24 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
9. | ALA4418037 | B | Inhibition of ACMSD in human primary hepatocytes assessed as increase in NAD\"\" concentration following compound replacement every 24 hrs by LC-MS/MS analysis relative to control | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
10. | ALA4418042 | B | Inhibition of ACMSD in in human Hepa1-6 cells assessed as increase in Sod2 mRNA expression incubated for 24 hrs by RT-qPCR analysis | Homo sapiens | 1 | ALA4417632 | cell-based format | Patent Bioactivity Data | |
11. | ALA4420580 | B | Inhibition of human recombinant ACMSD1 expressed in Escherichia coli BL21 (DE3) cells assessed as reduction in conversion of 3-OH-anthranilic acid into ACMS by spectrophotometry | Homo sapiens | 15 | ALA4420067 | cell-based format | Patent Bioactivity Data | |
12. | ALA4775521 | B | Inhibition of human ACMSD assessed as QUIN level at 1 mM by HPLC analysis (Rvb = 16.4 +/- 2.9%) | Homo sapiens | 26 | ALA4765479 | single protein format | Scientific Literature | |
13. | ALA4775522 | B | Inhibition of human ACMSD assessed as picolinic acid level at 1 mM by HPLC analysis (Rvb = 83.6 +/- 3.1%) | Homo sapiens | 26 | ALA4765479 | single protein format | Scientific Literature | |
14. | ALA4775523 | B | Inhibition of ACMSD (unknown origin) | Homo sapiens | 2 | ALA4765479 | single protein format | Scientific Literature | |
15. | ALA4775524 | B | Competitive inhibition of human ACMSD using ACMS substrate by spectrometry | Homo sapiens | 2 | ALA4765479 | single protein format | Scientific Literature | |
16. | ALA4775525 | B | Inhibition of human ACMSD using ACMS substrate by spectrometry | Homo sapiens | 16 | ALA4765479 | single protein format | Scientific Literature | |
17. | ALA4775526 | B | Inhibition of human ACMSD in presence of 10 uM 3-HAA by coupled assay | Homo sapiens | 1 | ALA4765479 | single protein format | Scientific Literature |