# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4020645 | B | Inhibition of interaction of CD40 in human THP-1 cells with recombinant human CD40L assessed as reduction in CD40L-induced MCH-2 upregulation after 48 hrs by DAPI-staining based flow cytometric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
2. | ALA4020646 | B | Inhibition of human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction incubated for 1 hr by ELISA-type assay | Homo sapiens | 10 | protein format | Scientific Literature | ||
3. | ALA4020649 | B | Inhibition of interaction of CD40 (unknown origin) transfected in HEK Blue cells with recombinant human CD40L assessed as reduction in CD40L-induced NF-kappaB activation after 18 hrs by spectrophotometry based SEAP reporter gene assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4020653 | B | Inhibition of interaction of CD40 in human B cells with recombinant human CD40L assessed as reduction in CD40L-induced cell proliferation after 48 hrs by BrdU incorporation-based ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA4020654 | B | Inhibition of interaction of CD40 in promoter/enhancer region of aicda-fused Ds-Red reporter transfected human B cells with recombinant human CD40L assessed as reduction in CD40L/IL-4-induced B cell activation by measuring AID expression after 2 days by flow cytometric analysis | Homo sapiens | 3 | assay format | Scientific Literature | ||
6. | ALA4020659 | B | Ratio of IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in presence of Triton-X 100 to IC50 for human Fc-conjugated CD40/FLAG-tagged biotinylated CD40L costimulatory protein-protein interaction in absence of Triton-X 100 | Homo sapiens | 4 | protein format | Scientific Literature |