| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4017369 | B | Inhibition of human N-terminal GST-tagged MLL1 (3735 to 3973 residues) interaction with human full length N-terminal 6xHis-tagged ASH2L/N-terminal 6xHis-tagged human full length RbBP5/human N-terminal 6xHis-tagged WDR5/human full length N-terminal 6xHis-tagged DPY30 assessed as decrease in H3K4me1-2 methylation preincubated for 30 mins followed by SAM/nucleosome mixture addition measured after 120 mins in absence of light by AlphaLISA assay | Homo sapiens | 19 | protein format | Scientific Literature | ||
| 2. | ALA4605328 | B | Inhibition of MLL1/WDR5/RBBP5/ASH2L/DPY30 complex (unknown origin) assessed as reduction in histone methyltransferase activity | Homo sapiens | 4 | protein format | Scientific Literature | ||
| 3. | ALA4619368 | B | Inhibition of recombinant human MLL1 complex (MLL1/Ash2L/RbBP5/WDR5/DPY-30) expressed in Escherichia coli Rosetta 2 (DE3) cells using H3 (1 to 21) peptide as substrate incubated for 1 hr in presence of 3[H] SAM by AlphaLISA assay | Homo sapiens | 19 | cell-based format | Scientific Literature |
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