# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA866004 | B | Agonist like activity at skeletal junction sarcoplasmic reticulum RyR1/FKBP12 complex assessed as increase in [3H]ryanodine binding | Homo sapiens | 13 | protein complex format | Scientific Literature | ||
2. | ALA4736774 | B | Stabilization of FKBP12/RyR1 protein-protein interaction in human myotubes assessed as reversal of SIN1-induced reduction in FKBP12/RyR1 co-localization by measuring increase in FKBP12/RyR1 co-localization at 150 nM by in situ proximity ligation assay relative to control | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
3. | ALA4736775 | B | Stabilization of FKBP12/RyR1 protein-protein interaction in human myotubes assessed as reversal of SIN1-induced reduction in FKBP12/RyR1 co-localization at 150 nM by in situ proximity ligation assay relative to control | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
4. | ALA4736776 | B | Effect on FKBP12/RyR1 protein-protein interaction in human myotubes by in situ proximity ligation assay | Homo sapiens | 2 | tissue-based format | Scientific Literature | ||
5. | ALA4736777 | B | Stabilization of FKBP12/RyR1 protein-protein interaction in human 8220 myoblast-derived myotubes assessed as reversal of SIN1-induced intracellular calcium leakage at 150 nM preincubated for 12 hrs followed by SIN1 stimulation and measured after 6 hrs by fura-2 AM dye based fluorescence assay relative to control | Homo sapiens | 16 | tissue-based format | Scientific Literature |