| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993207 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA4219613 | B | Inhibition of recombinant human glycine receptor alpha3beta expressed in HEK293 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4219622 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4219623 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in current response after 18 to 24 hrs by membrane potential blue dye based FLIPR assay relative to glycine | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4219931 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4219937 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293 cells assessed as potentiation of glycine-induced calcium flux by calcium dye-5 based FLIPR assay relative to glycine | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4219940 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced response at 5.9 uM by fluorescence based HTS assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA4219941 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux at 10 uM by HT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 9. | ALA4219942 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC20 glycine-induced ion flux by HT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 10. | ALA4219943 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in CHO cells assessed as potentiation of EC5 to EC10 glycine-induced response at 10 uM by manual patch clamp assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 11. | ALA4251999 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins by FLIPR assay | Homo sapiens | 170 | cell-based format | Scientific Literature | ||
| 12. | ALA4252012 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 3.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4252013 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 1.6 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4252014 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.8 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4252015 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.4 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4252016 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux by measuring leftward fold shift in glycine EC50 at 0.2 uM measured for 4 mins by Schild plot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4252021 | B | Positive allosteric modulation of human GlyRalpha3beta expressed in HEK293T cells assessed as increase in glycine-induced chloride ion flux measured for 4 mins in presence of GlyRs inhibitor strychnine by FLIPR assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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